Benzenepentanoyl chloride, 4-methyl-

Base Information

• Chemical Name: Benzenepentanoyl chloride, 4-methyl-
• CAS No.: 100388-65-6
• Molecular Formula: C12H15ClO
• Molecular Weight: 210.704
• Mol file: 100388-65-6.mol

Synonyms:

Chemical Property of Benzenepentanoyl chloride, 4-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepentanoyl chloride, 4-methyl-

There total 3 articles about Benzenepentanoyl chloride, 4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(p-tolyl)pentanoic acid (777-93-5) → 5-(p-tolyl)pentanoyl chloride (100388-65-6)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; toluene; at 80 ℃; for 2h;

DOI:10.1016/j.tetasy.2013.02.015

Reference yield:

(3-carboxypropyl)(triphenyl)phosphonium bromide (17857-14-6) → 5-(p-tolyl)pentanoyl chloride (100388-65-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran; dichloromethane / 20 h / 0 - 20 °C

2: hydrogen; 50% palladium on charcoal / ethanol / 6 h / 50 °C

3: thionyl chloride / N,N-dimethyl-formamide; toluene / 2 h / 80 °C

With thionyl chloride; 50% palladium on charcoal; potassium tert-butylate; hydrogen; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.tetasy.2013.02.015

Reference yield:

5-(p-tolyl)pent-4-enoic acid (5724-05-0) → 5-(p-tolyl)pentanoyl chloride (100388-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; 50% palladium on charcoal / ethanol / 6 h / 50 °C

2: thionyl chloride / N,N-dimethyl-formamide; toluene / 2 h / 80 °C

With thionyl chloride; 50% palladium on charcoal; hydrogen; In ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.tetasy.2013.02.015

upstream raw materials:

(3-carboxypropyl)(triphenyl)phosphonium bromide

5-(p-tolyl)pent-4-enoic acid

5-(p-tolyl)pentanoic acid

Downstream raw materials:

tert-butyl (5R,7S)-2,2-dimethyl-7-{1-methyl-5-[5-(4-methylphenyl)pentanoyl]-1H-pyrrol-2-yl}-3-oxa-1-azaspiro[4.4]nonane-1-carboxylate

1-{5-[(1S,3R)-3-amino-3-(hydroxymethyl)cyclopentyl]-1-methyl-1H-pyrrol-2-yl}-5-(4-methylphenyl)pentan-1-one

(S)-3[1-oxo-5-(4-methylphenyl)pentyl]-4-(phenylmethyl)-2-oxazolidinone

Refernces