1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene

Base Information

• Chemical Name: 1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene
• CAS No.: 10191-42-1
• Molecular Formula: C₁₉H₂₂N₂
• Molecular Weight: 278.397
• DSSTox Substance ID: DTXSID80274469
• Wikidata: Q27163970
• Mol file: 10191-42-1.mol

Synonyms:Tripyrolidine;1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene;10191-42-1;Spectrum_000171;Prestwick0_000262;Prestwick1_000262;Spectrum2_000845;Spectrum3_000648;Spectrum4_000375;CBMicro_025332;Oprea1_093114;KBioGR_000869;KBioSS_000651;(E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine;2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)prop-1-enyl]pyridine;DivK1c_000297;SPBio_000829;SPBio_002323;KBio1_000297;KBio2_000651;KBio2_003219;KBio2_005787;KBio3_001475;DTXSID80274469;CBEQULMOCCWAQT-UHFFFAOYSA-N;NINDS_000297;FT-0773110;Q27163970

Chemical Property of 1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene

Chemical Property:

• PSA: 16.13000
• LogP: 3.85540
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 278.178298710
• Heavy Atom Count: 21
• Complexity: 336

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3

Technology Process of 1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene

There total 6 articles about 1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-[2]pyridyl-3-pyrrolidino-1-p-tolyl-propan-1-ol (70708-28-0) → triprolidine (486-12-4,10191-42-1,13573-69-8)

Guidance literature:

1-[2]pyridyl-3-pyrrolidino-1-p-tolyl-propan-1-ol; With sulfuric acid; In water; at 25 - 105 ℃;

With sodium hydroxide; In water; at 5 - 30 ℃; for 4h; Product distribution / selectivity;

Reference yield:

2-(4-toluoyl)pyridine (78539-88-5) + [2-(Pyrrolidin-1-yl)ethyl]triphenylphosphonium bromide → triprolidine (486-12-4,10191-42-1,13573-69-8) + (Z)-triprolidine (13573-69-8)

Guidance literature:

With potassium tert-butylate; In dichloromethane; at 10 ℃; for 3h;

Reference yield:

2-(4-toluoyl)pyridine (78539-88-5) + [2-(Pyrrolidin-1-yl)ethyl]triphenylphosphonium bromide → triprolidine (486-12-4,10191-42-1,13573-69-8)

Guidance literature:

2-(4-toluoyl)pyridine; [2-(Pyrrolidin-1-yl)ethyl]triphenylphosphonium bromide; With potassium tert-butylate; In dichloromethane; at 10 - 20 ℃;

With methanesulfonic acid; at 190 ℃; for 6h; Further stages;

DOI:10.1080/00304940902802370

upstream raw materials:

2-(4-toluoyl)pyridine

1-[2]pyridyl-3-pyrrolidino-1-p-tolyl-propan-1-ol

Downstream raw materials:

Pro-Actidil

Refernces

• 1、 -. "A PROCESS FOR PREPARATION OF E-ISOMER OF 1-(4-METHYLPHENYL)- 1-(2-PYRID YL)-3-PYRROLIDINO PROP-1-ENE AND ACID ADDITION SALTS THEREOF". Page/Page column 5; 9-10. . Retrieved 2009/08/14.
• 2、 -. "Use of a compound in providing refreshedness on waking and a method for the treatment of drowsiness therewith". . . Retrieved 2008/06/13.