hex-5-yn-1-amine hydrochloride

Base Information

• Chemical Name: hex-5-yn-1-amine hydrochloride
• CAS No.: 102169-54-0
• Molecular Formula: C6H11N.ClH
• Molecular Weight: 133.621
• Mol file: 102169-54-0.mol

Synonyms:1-amino-5-hexyne hydrochloride;hex-5-ynylamine,hydrochloride;5-hexyn-1-amine hydrochloride;hex-5-yn-1-amine hydrochloride;6-Amino-1-hexyl phosphate;6-amino-1-hexyne hydrochloride;6-aminohex-1-yne hydrochloride;6-Amino-1-hexanol-phosphate;6-aminohexylphosphate;6-aminohexyne hydrochloride;

Chemical Property of hex-5-yn-1-amine hydrochloride

Chemical Property:

• Melting Point: 172 °C
• PSA: 26.02000
• LogP: 2.25090

Purity/Quality:

99% ^*data from raw suppliers

Hex-5-yn-1-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of hex-5-yn-1-amine hydrochloride

There total 7 articles about hex-5-yn-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-amino-5-hexyne (15252-45-6) → hex-5-yn-1-amine monohydrochloride (102169-54-0)

Guidance literature:

With hydrogenchloride; In diethyl ether;

Reference yield: 82.0%

2-(hex-5-yn-1-yl)isoindole-1,3-dione (6097-08-1) → hex-5-yn-1-amine monohydrochloride (102169-54-0)

Guidance literature:

2-(hex-5-yn-1-yl)isoindole-1,3-dione; With hydrazine hydrate; In ethanol; for 1h; Reflux;

With hydrogenchloride; In water;

DOI:10.1016/j.bmc.2013.04.081

Reference yield:

5-hexyl-1-ol (928-90-5) → hex-5-yn-1-amine monohydrochloride (102169-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 0 h / 18 °C

2.1: sodium azide / N,N-dimethyl-formamide; diethyl ether / 0.08 h / 20 °C

2.2: 5.5 h

2.3: pH 1

With pyridine; sodium azide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.201605460

upstream raw materials:

1-amino-5-hexyne

5-hexynonitrile

2-(hex-5-yn-1-yl)isoindole-1,3-dione

5-hexyl-1-ol

Downstream raw materials:

N-(hex-5-yn-1-yl)-4-methylbenzenesulfonamide

N-(hex-5-yn-1-yl)-2-iodoacetamide

C₁₃H₁₃ClN₂O₃

C₁₃H₁₃ClN₂O₃

Refernces

• 1、 Li, Wei,Schneider, Christopher M.,Georg, Gunda I.. "Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro-Stephens Coupling/Alkyne Reduction Tandem Reactions". . p. 3902 - 3905. Retrieved 2015.
• 2、 Wu, Junzhou,Tang, Xinjing. "Synthesis and enzymatic incorporation of photolabile dUTP analogues into DNA and their applications for DNA labeling". supporting information. p. 6205 - 6211. Retrieved 2013/10/21.