Clominorex

Base Information

• Chemical Name: Clominorex
• CAS No.: 3876-10-6
• Molecular Formula: C9H9 Cl N2 O
• Molecular Weight: 196.636
• Hs Code.: 2934999090
• NSC Number: 139299
• UNII: O1R2462WA0
• DSSTox Substance ID: DTXSID30863286
• Nikkaji Number: J8.270H
• Wikipedia: Clominorex
• Wikidata: Q5134931
• NCI Thesaurus Code: C72177
• ChEMBL ID: CHEMBL2104179
• Mol file: 3876-10-6.mol

Synonyms:CLOMINOREX;3876-10-6;5-(4-chlorophenyl)-4,5-dihydro-1,3-oxazol-2-amine;McN-1107;NSC-139299;2-Oxazolamine, 5-(4-chlorophenyl)-4,5-dihydro-;2-Amino-5-(p-chlorophenyl)-2-oxazoline;MeN-1107;O1R2462WA0;NSC139299;2-Oxazoline, 2-amino-5-(p-chlorophenyl)-;Clominorexum;CLOMINOREX [INN];Clominorex (USAN/INN);Clominorex [USAN:INN];CLOMINOREX [USAN];SCHEMBL121090;UNII-O1R2462WA0;CHEMBL2104179;McN 1107;DTXSID30863286;5-(4-chlorophenyl)oxazolidin-2-imine;AKOS006271734;NSC 139299;2-amino-5-(p-chlorphenyl)-2-oxazolin;5-(4-Chlorophenyl)-1,3-oxazolidin-2-imine;2-Amino-5-(4-chlorphenyl)-4,5-dihydrooxazol;D03552;Q5134931;Z1198155407

Chemical Property of Clominorex

Chemical Property:

• Vapor Pressure: 0.000277mmHg at 25°C
• Boiling Point: 322.6°Cat760mmHg
• Flash Point: 148.9°C
• PSA: 47.61000
• Density: 1.42g/cm³
• LogP: 1.86190
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 196.0403406
• Heavy Atom Count: 13
• Complexity: 212

Purity/Quality:

99%, ^*data from raw suppliers

2-OXAZOLAMINE, 5-(4-CHLOROPHENYL)-4,5-DIHYDRO- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(OC(=N1)N)C2=CC=C(C=C2)Cl
• Uses: Anorexic.

Technology Process of Clominorex

There total 3 articles about Clominorex which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloromandelonitrile (13312-83-9) → 5-(4-chloro-phenyl)-4,5-dihydro-oxazol-2-ylamine (3876-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / Heating

2: NaOAc / methanol

With lithium aluminium tetrahydride; sodium acetate; In methanol; diethyl ether;

DOI:10.1021/jm00339a011

Reference yield:

2-amino-1-(4-chlorophenyl)ethanol (41870-82-0) + bromocyane (506-68-3) → 5-(4-chloro-phenyl)-4,5-dihydro-oxazol-2-ylamine (3876-10-6)

Guidance literature:

With sodium acetate; In methanol;

DOI:10.1021/jm00339a011

Reference yield:

→ 5-(4-chloro-phenyl)-4,5-dihydro-oxazol-2-ylamine (3876-10-6)

Guidance literature:

2-Amino-1-(4-chlorphenyl)-ethanol, BrCN;

upstream raw materials:

2-amino-1-(4-chlorophenyl)ethanol

bromocyane

4-chloromandelonitrile