Benzenebutanol, 2-methoxy-

Base Information

• Chemical Name: Benzenebutanol, 2-methoxy-
• CAS No.: 10493-38-6
• Molecular Formula: C11H16O2
• Molecular Weight: 180.247
• Mol file: 10493-38-6.mol

Synonyms:Benzenebutanol, 2-methoxy-

Chemical Property of Benzenebutanol, 2-methoxy-

Chemical Property:

• PSA: 29.46000
• LogP: 2.01020

Purity/Quality:

99% ^*data from raw suppliers

BENZENEBUTANOL,2-METHOXY- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenebutanol, 2-methoxy-

There total 7 articles about Benzenebutanol, 2-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(2-methoxyphenyl)but-3-yn-1-ol (92587-67-2) → 4-(2-methoxyphenyl)-1-butanol (10493-38-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.08.029

Reference yield:

Ethyl 4-(2-Methoxyphenyl)-butanoate (33209-76-6) → 4-(2-methoxyphenyl)-1-butanol (10493-38-6)

Guidance literature:

With lithium aluminium tetrahydride;

Reference yield:

4-iodoanisol (529-28-2) → 4-(2-methoxyphenyl)-1-butanol (10493-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine / 24 h / 0 °C / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / Inert atmosphere

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; 1: Sonogashira coupling;

DOI:10.1016/j.bmcl.2011.08.029

upstream raw materials:

Ethyl 4-(2-Methoxyphenyl)-butanoate

oxirane

4-(2-methoxyphenyl)but-3-yn-1-ol

4-iodoanisol

Downstream raw materials:

2-(4-bromobutyl]anisole

1-(2-benzofuranylmethyl)-4-[4-(2-methoxyphenyl)butyl]piperazine

Refernces

• 1、 Mimori, Seisuke,Okuma, Yasunobu,Kaneko, Masayuki,Kawada, Koichi,Nomura, Yasuyuki,Murakami, Yasuoki,Hamana, Hiroshi. "Discovery of synthetic methoxy-substituted 4-phenylbutyric acid derivatives as chemical chaperones". supporting information. p. 1051 - 1052. Retrieved 2013/09/24.
• 2、 CAGNIANT. "Not available". . p. 889 - 891. Retrieved 2007/10/04.