2-(4-bromobutyl]anisole

Base Information

• Chemical Name: 2-(4-bromobutyl]anisole
• CAS No.: 151719-88-9
• Molecular Formula: C₁₁H₁₅BrO
• Molecular Weight: 243.143
• Mol file: 151719-88-9.mol

Synonyms:2-(4-bromobutyl]anisole

Chemical Property of 2-(4-bromobutyl]anisole

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

1-(4-Bromobutyl)-2-methoxybenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-bromobutyl]anisole

There total 6 articles about 2-(4-bromobutyl]anisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-(2-methoxyphenyl)-1-butanol (10493-38-6) → 2-(4-bromobutyl]anisole (151719-88-9)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In diethyl ether; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.08.029

Reference yield: 33.0%

1,4-dibromo-butane (110-52-1) + 2-bromoanisole (578-57-4) → 2-(4-bromobutyl]anisole (151719-88-9)

Guidance literature:

2-bromoanisole; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 2.16667h;

1,4-dibromo-butane; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃;

DOI:10.1021/acs.orglett.0c03090

Reference yield:

2-bromoanisole (578-57-4) → 2-(4-bromobutyl]anisole (151719-88-9)

Guidance literature:

In tetrahydrofuran;

upstream raw materials:

2-bromoanisole

4-(2-methoxyphenyl)but-3-yn-1-ol

4-iodoanisol

4-(2-methoxyphenyl)-1-butanol

Downstream raw materials:

1-(2-benzofuranylmethyl)-4-[4-(2-methoxyphenyl)butyl]piperazine

Refernces

• 1、 Maddocks, Christopher J.,Ermanis, Kristaps,Clarke, Paul A.. "Asymmetric "clip-Cycle" Synthesis of Pyrrolidines and Spiropyrrolidines". supporting information. p. 8116 - 8121. Retrieved 2020/11/02.
• 2、 -. "3-(heteroaryl)-1-?(2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1-?(2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility". . . Retrieved 2008/06/13.