N-Methyl-N-(trimethylsilyl)acetamide

Base Information

• Chemical Name: N-Methyl-N-(trimethylsilyl)acetamide
• CAS No.: 7449-74-3
• Molecular Formula: C6H15NOSi
• Molecular Weight: 145.277
• Hs Code.: 29319090
• European Community (EC) Number: 231-217-0
• NSC Number: 142435
• UNII: W0IWF6UKW5
• DSSTox Substance ID: DTXSID0064707
• Nikkaji Number: J208.694H
• Wikidata: Q72492199
• Mol file: 7449-74-3.mol

Synonyms:N-Methyl-N-(trimethylsilyl)acetamide;7449-74-3;N-Methyl-N-trimethylsilylacetamide;Acetamide, N-methyl-N-(trimethylsilyl)-;N-Trimethylsilyl-N-methylacetamide;W0IWF6UKW5;N-Methylacetamide, TMS derivative;EINECS 231-217-0;NSC 142435;NSC-142435;N-Methyl-N-TMS-acetamide;NSC142435;UNII-W0IWF6UKW5;SCHEMBL537585;DTXSID0064707;QHUOBLDKFGCVCG-UHFFFAOYSA-;AMY3269;N-Methyl-N-trimethylsilyacetamide;N-trimethylsilyl-N'-methylacetamide;MFCD00040758;AKOS006229818;FS-4239;CS-0179366;FT-0763229;M0536;D91352;N-Methyl-N-trimethylsilylacetamide, for GC derivatization, >=97.0% (GC)

Chemical Property of N-Methyl-N-(trimethylsilyl)acetamide

Chemical Property:

• Appearance/Colour: clear light yellow clear liquid
• Vapor Pressure: 6.41mmHg at 25°C
• Refractive Index: n20/D 1.439
• Boiling Point: 139.5 °C at 760 mmHg
• PKA: -0.11±0.70(Predicted)
• Flash Point: 38.2 °C
• PSA: 20.31000
• Density: 0.866 g/cm³
• LogP: 1.29960
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 145.092290636
• Heavy Atom Count: 9
• Complexity: 117

Purity/Quality:

99.9% ^*data from raw suppliers

N-Methyl-N-trimethylsilylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 37/39-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)N(C)[Si](C)(C)C
• Uses: N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:??????? Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.??????? Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

Technology Process of N-Methyl-N-(trimethylsilyl)acetamide

There total 8 articles about N-Methyl-N-(trimethylsilyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-methyl-acetamide (79-16-3) + chloro-trimethyl-silane (75-77-4) → N-methyl-N-trimethylsilylacetamide (7449-74-3)

Guidance literature:

With triethylamine; In hexane; at 30 ℃; for 1h; Industry scale;

Reference yield:

N-Methyl-N-<1-(trimethylsiloxy)vinyl>acetamid (23184-22-7) → N-methyl-N-trimethylsilylacetamide (7449-74-3)

Guidance literature:

at 180 - 200 ℃; under 180 Torr;

DOI:10.1016/S0022-328X(00)88613-1

Reference yield:

N-methyltrimethylsilylacetamide (23138-68-3) → N-methyl-N-trimethylsilylacetamide (7449-74-3)

Guidance literature:

at 180 - 200 ℃; under 8 Torr;

DOI:10.1016/S0022-328X(00)88613-1

upstream raw materials:

N-methyl-acetamide

chloro-trimethyl-silane

N-Methyl-N-<1-(trimethylsiloxy)vinyl>acetamid

N-methyltrimethylsilylacetamide

Downstream raw materials:

N-Methyl-N-(β-trimethylsiloxy-β-phenyl-aethyl)-acetamid

1-(Trimethylsilyloxy)cyclohexene

N-methyldiacetamide

Essigsaeure-

Refernces

• 1、 -. "Carbacephalosporin compound, their preparation and use". . . Retrieved 2008/06/13.
• 2、 Kramarova, V.P.,Shipov, A.G.,Baukov, Yu.I.. "SYNTHESIS OF N-(SILATRANYLMETHYL)-SUBSTITUTED LACTAMS AND CARBOXYLIC ACID AMIDES". . p. 2113 - 2119. Retrieved 2007/10/02.