3-Methoxy-2-methylpyridine

Base Information

• Chemical Name: 3-Methoxy-2-methylpyridine
• CAS No.: 26395-26-6
• Molecular Formula: C7H9NO
• Molecular Weight: 123.155
• Hs Code.: 2933399090
• European Community (EC) Number: 247-652-4
• DSSTox Substance ID: DTXSID00180997
• Nikkaji Number: J248.921J
• Wikidata: Q83051616
• Mol file: 26395-26-6.mol

Synonyms:3-Methoxy-2-methylpyridine;26395-26-6;3-Methoxy-2-picoline;3-methoxy-2-methyl-pyridine;EINECS 247-652-4;2-methyl-3-methoxypyridine;Pyridine,3-methoxy-2-methyl-;SCHEMBL1179274;Pyridine, 3-methoxy-2-methyl-;AMY6257;DTXSID00180997;QRCUQLANPHYVEH-UHFFFAOYSA-N;MFCD00128178;AKOS006272152;AB03569;2-BROMO-4,6-DINITROBENZOICACID;AS-41780;CS-0197095;FT-0654217;EN300-177112;A818423;Z1198150814

Chemical Property of 3-Methoxy-2-methylpyridine

Chemical Property:

• Vapor Pressure: 1.72mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 173.1 °C at 760 mmHg
• PKA: 6.18±0.10(Predicted)
• Flash Point: 60.9 °C
• PSA: 22.12000
• Density: 1.001 g/cm³
• LogP: 1.39860
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methoxy-2-methyl-pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC=N1)OC

Technology Process of 3-Methoxy-2-methylpyridine

There total 12 articles about 3-Methoxy-2-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloro-3-methoxypyridine (52605-96-6) + trimethylaluminum (75-24-1) → 3-methoxy-2-methylpyridine (26395-26-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; hexane; for 5.5h; Heating;

DOI:10.3987/COM-89-S75

Reference yield: 80.0%

3-methoxy-2-methylpyridine 1-oxide (35392-65-5) → 3-methoxy-2-methylpyridine (26395-26-6)

Guidance literature:

With phosphorus trichloride; In dichloromethane; at 20 ℃; for 12h;

Reference yield: 60.0%

2-bromo-3-methoxypyridine (24100-18-3) + methylmagnesium bromide (75-16-1) → 3-methoxy-2-methylpyridine (26395-26-6)

Guidance literature:

2-bromo-3-methoxypyridine; With bis(triphenylphosphine)nickel(II) chloride; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

methylmagnesium bromide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03935

upstream raw materials:

2-chloro-3-methoxypyridine

trimethylaluminum

3-methoxy-2-methylpyridine 1-oxide

2-methyl-3-pyridinol

Downstream raw materials:

1-(3-methoxypyridin-2-yl)-2-propanone

3-methoxy-pyridine-2-carbaldehyde

6-hydroxy-3-methoxy-2-methylpyridine 1-oxide

4-Chloro-3-methoxy-2-methyl-pyridine

Refernces

• 1、 -. "Multi-substituted amine compound and its preparation and use (by machine translation)". Paragraph 0748; 0752-0755. . Retrieved 2018/04/27.
• 2、 Largeron, Martine,Auzeil, Nicolas,Bacque, Eric,Fleury, Maurice-Bernard. "Influence of steric crowding on the electrochemical reduction of substituted tertiary pyridylcarboxamides in aqueous acidic medium". . p. 495 - 501. Retrieved 2007/10/03.