N'-formyl-2-hydroxybenzohydrazide

Base Information

• Chemical Name: N'-formyl-2-hydroxybenzohydrazide
• CAS No.: 1010-85-1
• Molecular Formula: C8H8 N2 O3
• Molecular Weight: 180.163
• DSSTox Substance ID: DTXSID101280501
• Metabolomics Workbench ID: 58302
• Nikkaji Number: J1.726.998D
• Wikidata: Q27123501
• Mol file: 1010-85-1.mol

Synonyms:N'-formyl-2-hydroxybenzohydrazide;N-formylsalicylhydrazide;H3fshz;N-formylsalicylhydrazine;N-formylsalicylhydrazidate;N-[(2-hydroxybenzoyl)amino]formamide;1010-85-1;SCHEMBL447422;CHEBI:52604;DTXSID101280501;2-Hydroxybenzoic acid 2-formylhydrazide;Q27123501

Chemical Property of N'-formyl-2-hydroxybenzohydrazide

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 180.05349212
• Heavy Atom Count: 13
• Complexity: 196

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NNC=O)O

Technology Process of N'-formyl-2-hydroxybenzohydrazide

There total 6 articles about N'-formyl-2-hydroxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

formic acid (64-18-6) + 2-Hydroxybenzoylhydrazine (936-02-7) → N'-formyl-2-hydroxybenzohydrazide (1010-85-1)

Guidance literature:

With benzoyl chloride; triethylamine; In chloroform; at 0 - 25 ℃;

DOI:10.1039/b109517j

Reference yield:

N'-[2-(4-nitrophenyl)-2-ethylidene]-2-hydroxybenzohydrazide → N'-formyl-2-hydroxybenzohydrazide (1010-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / water

2: 25 h / Reflux

With sulfuric acid; In water;

DOI:10.1002/jhet.2516

Reference yield:

N'-[2-(4-chlorophenyl)-2-ethylidene]-2-hydroxybenzohydrazide → N'-formyl-2-hydroxybenzohydrazide (1010-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / water

2: 25 h / Reflux

With sulfuric acid; In water;

DOI:10.1002/jhet.2516

upstream raw materials:

formic acid

2-Hydroxybenzoylhydrazine

methyl salicylate

Downstream raw materials:

2-(1,3,4-oxadiazol-2-yl)-phenol

2-(2-hydroxyphenyl)-1,3,4-thiadiazole

Refernces

• 1、 Lin, Shen,Liu, Shi-Xiong,Huanga, Jian-Quan,Lina, Chi-Chang. "Four novel nanometer-sized cobalt azametallacrown complexes". . p. 1595 - 1601. Retrieved 2007/10/03.