Ethyl thiazole-5-carboxylate

Base Information

• Chemical Name: Ethyl thiazole-5-carboxylate
• CAS No.: 32955-22-9
• Molecular Formula: C6H7NO2S
• Molecular Weight: 157.193
• Hs Code.: 2934100090
• Mol file: 32955-22-9.mol

Synonyms:Ethyl5-thiazolecarboxylate;5-Thiazolecarboxylic acid, ethyl ester;Ethyl thiazole-5-carboxylate;

Chemical Property of Ethyl thiazole-5-carboxylate

Chemical Property:

• Vapor Pressure: 0.0492mmHg at 25°C
• Refractive Index: 1.53
• Boiling Point: 235.7 °C at 760 mmHg
• PKA: 0.90±0.10(Predicted)
• Flash Point: 96.4 °C
• PSA: 67.43000
• Density: 1.242 g/cm³
• LogP: 1.31980
• Storage Temp.: Keep Cold

Purity/Quality:

99% ^*data from raw suppliers

Ethyl thiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl thiazole-5-carboxylate

There total 5 articles about Ethyl thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

thiophene (188290-36-0,8014-23-1,25233-34-5) + ethyl 2-iodothiazole-5-carboxylate (83553-48-4) → ethyl thiazole-5-carboxylate (32955-22-9) + ethyl 3-(2-thienyl)isothiazole-4-carboxylate (1240399-14-7)

Guidance literature:

In acetonitrile; for 13.5h; UV-irradiation;

DOI:10.1002/ejoc.201000096

Reference yield: 95.0%

5-bromo-1,3-thiazole (3034-55-7) + ethanol (64-17-5) + carbon monoxide (201230-82-2) → ethyl thiazole-5-carboxylate (32955-22-9)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 100 ℃; under 5171.5 Torr;

DOI:10.1016/S0040-4039(01)81726-3

Reference yield: 60.0%

thiocarboxamide (115-08-2) + ethyl 2-chloro-3-oxopropanoate (33142-21-1) → ethyl thiazole-5-carboxylate (32955-22-9)

Guidance literature:

In acetone; for 2h; Heating;

DOI:10.1021/jm970636+

upstream raw materials:

thiocarboxamide

ethyl 2-chloro-3-oxopropanoate

5-bromo-1,3-thiazole

ethanol

Downstream raw materials:

thiazole-5-carboxylic acid

thiazole-5-carboxamide

thiazol-5-yl-methanol

Refernces

• 1、 Wang, Liang,Dai, Fu-Ying,Zhu, Jie,Dong, Kui-Kui,Wang, Yu-Liang,Chen, Tian. "Synthesis and antibacterial activities of pleuromutilin derivatives with thiazole-5-carboxamide and thioether moiety". experimental part. p. 313 - 316. Retrieved 2011/10/05.
• 2、 -. "Retroviral protease inhibiting compounds". Page 44. . Retrieved 2010/01/31.