5-Bromothiazole

Base Information

• Chemical Name: 5-Bromothiazole
• CAS No.: 3034-55-7
• Molecular Formula: C3H2BrNS
• Molecular Weight: 164.026
• Hs Code.: 29341000
• Mol file: 3034-55-7.mol

Synonyms:Thiazole, 5-bromo-;

Chemical Property of 5-Bromothiazole

Chemical Property:

• Vapor Pressure: 0.535mmHg at 25°C
• Melting Point: 131-132 °C(Solv: ligroine (8032-32-4))
• Refractive Index: 1.5955
• Boiling Point: 197.365 °C at 760 mmHg
• PKA: 1.00±0.10(Predicted)
• Flash Point: 73.164 °C
• PSA: 41.13000
• Density: 1.857 g/cm³
• LogP: 1.90560
• Sensitive.: Moisture Sensitive
• Water Solubility.: Soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-43
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromothiazole is used as a pharmaceutical intermediate and performance material.

Technology Process of 5-Bromothiazole

There total 5 articles about 5-Bromothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

5-bromo-2-aminothiazole (3034-22-8) → 5-bromo-1,3-thiazole (3034-55-7)

Guidance literature:

With phosphoric acid; nitric acid; sodium nitrite; In water; at 0 - 5 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.joc.7b00495

Reference yield: 35.0%

2,5-dibromo-1,3-thiazole (4175-78-4) → 5-bromo-1,3-thiazole (3034-55-7)

Guidance literature:

With acetic acid; zinc; Heating;

DOI:10.1007/BF00575251

Reference yield:

2-(trimethylsilyl)thiazole (79265-30-8) → 5-bromo-1,3-thiazole (3034-55-7) + 5-bromo-2-iodothiazole (108306-64-5)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1055/s-1986-31766

upstream raw materials:

5-bromo-2-aminothiazole

2,5-dibromo-1,3-thiazole

2-(trimethylsilyl)thiazole

1,3-thiazole

Downstream raw materials:

1-benzenesulfonyl-3-thiazol-5-yl-1H-indol-6-ylamine

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1,3-thiazole

5-(3-methylphenyl)-1,3-thiazole

(2,4-dimethylphenyl)(thiazol-5-yl)methanamine

Refernces

• 1、 Walke,Bonde,Bhadane,Dangat,Jadhav. "Rapid kinetics and relative reactivity of some five membered aromatic heterocycles using hydrodynamic voltammetry". . p. 2239 - 2245. Retrieved 2016/02/27.
• 2、 Stanetty, Peter,Schnuerch, Michael,Mihovilovic, Marko D.. "Halogenated 2′-chlorobithiazoles via Pd-catalyzed cross-coupling reactions". . p. 3754 - 3761. Retrieved 2007/10/03.