2-Amino-2-phenylacetamide

Base Information

• Chemical Name: 2-Amino-2-phenylacetamide
• CAS No.: 700-63-0
• Molecular Formula: C8H10 N2 O
• Molecular Weight: 150.18
• European Community (EC) Number: 211-849-3
• NSC Number: 47695
• DSSTox Substance ID: DTXSID20863871
• Nikkaji Number: J54.048J
• Mol file: 700-63-0.mol

Synonyms:2-Amino-2-phenylacetamide;700-63-0;2-Amino-2-phenyl-acetamide;ACETAMIDE, 2-AMINO-2-PHENYL-;Benzeneacetamide, .alpha.-amino-;DL-2-PHENYLGLYCINAMIDE;Benzeneacetamide, alpha-amino-;H-Phg-NH HCl;NSC47695;EINECS 211-849-3;NSC 47695;BRN 0972472;1-14-00-00592 (Beilstein Handbook Reference);d-phenylglycine amide;MFCD06799064;aminophenylacetamide;H-Phg-NH2;WLN: ZYR&VZ;H-D-Phg-NH . HCl;alpha-Amino-benzeneacetamide;2-azanyl-2-phenyl-ethanamide;SCHEMBL544671;DTXSID20863871;AC-684;MFCD00025498;NSC-47695;STK097875;AKOS000204934;AKOS016038186;AKOS037748796;LS-8085;s10736;AS-58496;SY009237;SY017679;AM20041042;FT-0636162;FT-0650390;FT-0688396;P2402;EN300-25412;A836758;J-501016;Z57204607

Chemical Property of 2-Amino-2-phenylacetamide

Chemical Property:

• Melting Point: 130-131℃
• Boiling Point: 322.8±35.0 °C(Predicted)
• PKA: 15.61±0.50(Predicted)
• PSA: 69.11000
• Density: 1.178±0.06 g/cm3(Predicted)
• LogP: 1.57230
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: DMSO (Sparingly, Heated, Sonicated), Methanol (Slightly)
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 141

Purity/Quality:

98%,99%, ^*data from raw suppliers

DL-2-Phenylglycinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C(=O)N)N
• Uses: DL-2-Phenylglycinamide is used in the synthesis of enantiopure α-amino acids and amides. Also used in the preparation of HIV-1 reverse transcriptase inhibitors in the form of thiadiazole derivatives.

Technology Process of 2-Amino-2-phenylacetamide

There total 59 articles about 2-Amino-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C23H20N2O → (R)-phenylglycine amide (700-63-0,6485-52-5,6485-67-2,58429-87-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 760.051 Torr;

DOI:10.1021/acscatal.9b02739

Reference yield: 96.0%

D-phenylglycine methyl ester hydrochloride (19883-41-1,13226-98-7) → (R)-phenylglycine amide (700-63-0,6485-52-5,6485-67-2,58429-87-1)

Guidance literature:

With ammonia; water; In toluene;

DOI:10.1039/c2ob25472g

Reference yield: 95.1%

(R)-phenylglycine nitrile (45789-64-8) → (R)-phenylglycine amide (700-63-0,6485-52-5,6485-67-2,58429-87-1)

Guidance literature:

With sulfuric acid; In aq. phosphate buffer; at 5 ℃; for 22h; pH=7; Reagent/catalyst; Temperature; Time; pH-value; Catalytic behavior; Enzymatic reaction;

DOI:10.1021/op000055l

upstream raw materials:

ethyl 2-phenyl-2-aminoacetate

α-benzylideneamino-α-phenylacetamide

2-amino-2-phenylacetonitrile

2-phenylglycinonitrile hydrochloride

Downstream raw materials:

(R)-phenylglycine

phenyl-5 piperazinetrione-2,3,6

α-amino-4-methyl-deoxybenzoin

3-phenyl-2(1H)-pyrazinone

Refernces

• 1、 -. "COMPLEMENT MODULATORS AND RELATED METHODS". Paragraph 0422. . Retrieved 2020/10/20.
• 2、 -. "EGFR DIMER DISRUPTORS AND USE OF THE SAME". Paragraph 0142-0143. . Retrieved 2019/09/12.