ethyl 2-amino-2-phenylacetate

Base Information

• Chemical Name: ethyl 2-amino-2-phenylacetate
• CAS No.: 6097-58-1
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Mol file: 6097-58-1.mol

Synonyms:Ethyl phenylglycinate,DL;(RS)-phenylglycine ethyl ester;Ethyl 2-phenylglycinate;Ethyl DL-phenylglycinate;

Chemical Property of ethyl 2-amino-2-phenylacetate

Chemical Property:

• Boiling Point: 110-111 °C(Press: 4 Torr)
• PKA: 6.83±0.10(Predicted)
• PSA: 52.32000
• Density: 1.098±0.06 g/cm3(Predicted)
• LogP: 1.94980

Purity/Quality:

95% ^*data from raw suppliers

ETHYL 2-AMINO-2-PHENYLACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-amino-2-phenylacetate

There total 17 articles about ethyl 2-amino-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + phenylglycin (2835-06-5) → ethyl 2-phenyl-2-aminoacetate (6097-58-1,6152-27-8,15962-49-9,39251-40-6)

Guidance literature:

ethanol; phenylglycin; With thionyl chloride; Reflux;

With sodium hydrogencarbonate;

DOI:10.1016/j.tetasy.2010.02.011

Reference yield: 99.0%

phenylglycin (2835-06-5) → ethyl 2-phenyl-2-aminoacetate (6097-58-1,6152-27-8,15962-49-9,39251-40-6)

Guidance literature:

With thionyl chloride; In ethanol; at 0 - 90 ℃; for 5h;

DOI:10.1002/chem.201802465

Reference yield: 97.2%

phenylglyoxylic acid ethyl ester (1603-79-8) → ethyl 2-phenyl-2-aminoacetate (6097-58-1,6152-27-8,15962-49-9,39251-40-6)

Guidance literature:

With [pentamethylcyclopentadienyl*Ir(N-phenyl-2-pyridinecarboxamidate)Cl]; ammonium formate; In methanol; at 37 ℃; for 6h; chemoselective reaction;

DOI:10.1016/j.tetlet.2020.152196

upstream raw materials:

phenylglyoxylic acid ethyl ester

rac-Ala-OH

ethanol

phenylglycin

Downstream raw materials:

phenylglyoxylic acid ethyl ester

AlaOEt

2-cyclohexyl-2-dimethylamino-ethanol

Refernces

• 1、 Wang, Jiahua,Dai, Zonghao,Xiong, Cheng,Zhu, Jin,Lu, Jinrong,Zhou, Qingfa. "Palladium-Catalyzed Allylic Alkylation of Aldimine Esters with Vinyl-Cyclopropanes to Yield α,α-Disubstituted α-Amino Acid Derivatives". supporting information. p. 5105 - 5111. Retrieved 2019/11/11.
• 2、 Lin, Hua,Wang, Chao,Bannister, Thomas D.,Kamenecka, Theodore M.. "Site-Selective γ-C(sp3)?H and γ-C(sp2)?H Arylation of Free Amino Esters Promoted by a Catalytic Transient Directing Group". supporting information. p. 9535 - 9541. Retrieved 2018/07/14.