Alanine, ethyl ester (9CI)

Base Information

• Chemical Name: Alanine, ethyl ester (9CI)
• CAS No.: 17344-99-9
• Molecular Formula: C5H11 N O2
• Molecular Weight: 117.148
• Hs Code.: 2922499990
• Mol file: 17344-99-9.mol

Synonyms:Alanine,ethyl ester, DL- (8CI); DL-Alanine, ethyl ester; (?à)-Alanine ethyl ester; Ethyl DL-alaninate;O-Ethyl-DL-alanine

Chemical Property of Alanine, ethyl ester (9CI)

Chemical Property:

• Boiling Point: 48 °C(Press: 11 Torr)
• PKA: 8.03±0.29(Predicted)
• PSA: 52.32000
• Density: 0.987±0.06 g/cm3(Predicted)
• LogP: 0.59700
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%Min ^*data from raw suppliers

ethyl2-aminopropanoate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Alanine, ethyl ester (9CI)

There total 35 articles about Alanine, ethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl diazoalaninate (6111-99-5) → AlaOEt (17344-99-9)

Guidance literature:

With meso-tetraphenylporphyrin iron(III) chloride; ammonia; In tetrahydrofuran; for 0.0166667h;

DOI:10.1039/c7cc00003k

Reference yield: 86.0%

DL-alanine ethyl ester hydrochloride (617-27-6) → AlaOEt (17344-99-9)

Guidance literature:

With triethylamine; In water; at 20 ℃; for 0.5h;

Reference yield: 78.0%

C15H15N3O2 → AlaOEt (17344-99-9) + naphthalene-1,8-diamine (479-27-6)

Guidance literature:

With aluminium amalgam; In tetrahydrofuran; water; at 25 ℃;

DOI:10.1016/S0040-4039(00)01115-1

upstream raw materials:

2-oxo-propionic acid ethyl ester

ethyl 2-phenyl-2-aminoacetate

sodium ethanolate

ethanol

Downstream raw materials:

4-(2-hydroxy-ethyl)-3-methyl-morpholin-2-one

(+/-)-N,N-Bis-(2-hydroxy-ethyl)-alanin

[5-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-imidazol-1-yl]-acetone

[5-(3,4-dimethoxy-phenyl)-2-thioxo-2,3-dihydro-imidazol-1-yl]-acetone

Refernces

• 1、 Li, Xing-Shuo,Zhao, Liang-Liang,Wang, Xiao-Ke,Cao, Li,Shi, Xiao-Qian,Zhang, Rui,Qi, Jing. "Enantioselective [3 + 2] Annulation of Enals with 2-Aminoacrylates Catalyzed by N-Heterocyclic Carbene". . p. 3943 - 3946. Retrieved 2017.
• 2、 Bhimapaka, China Raju,Kasagani, Veera Prasad,Kurma, Siva Hariprasad. "Stereospecific Synthesis of 3,4-Dihydro-2 H-naphtho-1,4-oxazin-2-ones by Unification of Benzoxepine-4-carboxylates with Chiral Amino Acid Ethyl Esters". supporting information. p. 2976 - 2983. Retrieved 2020/03/23.
• 3、 Wang, Jiahua,Dai, Zonghao,Xiong, Cheng,Zhu, Jin,Lu, Jinrong,Zhou, Qingfa. "Palladium-Catalyzed Allylic Alkylation of Aldimine Esters with Vinyl-Cyclopropanes to Yield α,α-Disubstituted α-Amino Acid Derivatives". supporting information. p. 5105 - 5111. Retrieved 2019/11/11.