N,N'-Diacetylhydrazine

Base Information

• Chemical Name: N,N'-Diacetylhydrazine
• CAS No.: 3148-73-0
• Molecular Formula: C4H8N2O2
• Molecular Weight: 116.12
• Hs Code.: 29280090
• European Community (EC) Number: 221-576-1
• NSC Number: 42939
• UNII: YMR3ZF0Q4M
• DSSTox Substance ID: DTXSID7020390
• Nikkaji Number: J217.302F
• Wikidata: Q27149664
• ChEMBL ID: CHEMBL3091852
• Mol file: 3148-73-0.mol

Synonyms:1,2-diacetylhydrazine;N,N'-diacetylhydrazine

Chemical Property of N,N'-Diacetylhydrazine

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0Pa at 25℃
• Melting Point: 138-140 °C(lit.)
• Refractive Index: 1.4880 (estimate)
• Boiling Point: 349.9 °C at 760 mmHg
• PKA: 11.59±0.23(Predicted)
• Flash Point: 183.3 °C
• PSA: 58.20000
• Density: 1.091g/cm³
• LogP: -0.04460
• Storage Temp.: Store below +30°C.
• Sensitive.: Moisture Sensitive
• Solubility.: DMSO (Sparingly), Methanol (Slightly)
• Water Solubility.: Soluble
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 116.058577502
• Heavy Atom Count: 8
• Complexity: 96.6

Purity/Quality:

99.9% ^*data from raw suppliers

1,2-Diacetylhydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)NNC(=O)C

Technology Process of N,N'-Diacetylhydrazine

There total 28 articles about N,N'-Diacetylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic anhydride (108-24-7) → Diacetylhydrazin (3148-73-0)

Guidance literature:

With pyridine; aluminum oxide; hydrazine; at 131 - 133 ℃; for 5h; microwave irradiation;

DOI:10.1016/S0040-4039(02)00732-3

Reference yield: 98.0%

acetic anhydride (108-24-7) + acetic acid hydrazide (1068-57-1) → Diacetylhydrazin (3148-73-0)

Guidance literature:

In ethanol; water; ethyl acetate; at 40 - 45 ℃; for 4h;

Reference yield: 78.0%

ethyl acetate (141-78-6) + acetic acid hydrazide (1068-57-1) → Diacetylhydrazin (3148-73-0)

Guidance literature:

Amano PS Lipase; at 25 ℃; for 48h;

DOI:10.1055/s-1991-26462

upstream raw materials:

sodium acetate

hydrazodicarboxamide

acetic anhydride

acetic acid hydrazide

Downstream raw materials:

dimethylglyoxal

C₃₃H₄₈N₄O₂Si

5-methyl-1-phenyl-1H-tetrazole

acetamide

Refernces

• 1、 Astorga,Rebolledo,Gotor. "Synthesis of hydrazides through an enzymatic hydrazinolysis reaction". . p. 350 - 352. Retrieved 1991.
• 2、 -. "A PROCESS FOR THE PREPARATION OF [1,4,5]-OXADIAZEPINE DERIVATIVES". Page/Page column 7. . Retrieved 2008/06/13.
• 3、 Paul, Satya,Nanda, Puja,Gupta, Rajive,Loupy, André. "Ac2O-Py/basic alumina as a versatile reagent for acetylations in solvent-free conditions under microwave irradiation". . p. 4261 - 4265. Retrieved 2007/10/03.