trans-2,5-Difluorocinnamic acid

Base Information Edit

Chemical Name:trans-2,5-Difluorocinnamic acid
CAS No.:112898-33-6
Molecular Formula:C9H6 F2 O2
Molecular Weight:184.142
Hs Code.:29163990
European Community (EC) Number:628-615-5
Nikkaji Number:J911.587K
Wikidata:Q76146014
Mol file:112898-33-6.mol

Synonyms:trans-2,5-Difluorocinnamic acid;112898-33-6;2,5-Difluorocinnamic acid;(E)-3-(2,5-Difluorophenyl)acrylic acid;3-(2,5-Difluorophenyl)acrylic acid;375368-88-0;2,5-difluorocinnamicacid;(2E)-3-(2,5-difluorophenyl)prop-2-enoic acid;(E)-3-(2,5-difluorophenyl)prop-2-enoic acid;2-Propenoic acid, 3-(2,5-difluorophenyl)-, (2E)-;3-(2,5-difluorophenyl)prop-2-enoic acid;(2E)-3-(2,5-Difluorophenyl)acrylic acid;SCHEMBL65190;AMY2951;CK2545;MFCD00010318;AKOS009158337;CS-W017015;PS-6473;trans-2,5-Difluorocinnamic acid, 98%;NCGC00337138-01;AC-26150;EN300-53906;A21676;EN300-833007;(2E)-3-(2,5-Difluorophenyl)-2-propenoic acid;AB01331123-02;(2E)-3-(2,5-Difluorophenyl)-2-propenoic acid #;J-002867;F0001-0277;Z2942852737

Suppliers and Price of trans-2,5-Difluorocinnamic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
trans-2,5-Difluorocinnamic acid
50mg
$ 45.00

SynQuest Laboratories
trans-2,5-Difluorocinnamic acid 98%
100 g
$ 195.00

SynQuest Laboratories
trans-2,5-Difluorocinnamic acid 98%
5 g
$ 20.00

SynQuest Laboratories
trans-2,5-Difluorocinnamic acid 98%
25 g
$ 65.00

Sigma-Aldrich
trans-2,5-Difluorocinnamic acid 98%
5g
$ 105.00

Matrix Scientific
2,5-Difluorocinnamic acid
25g
$ 240.00

Matrix Scientific
2,5-Difluorocinnamic acid
10g
$ 112.00

Frontier Specialty Chemicals
trans-2,5-Difluorocinnamic acid 98%
1g
$ 31.00

Frontier Specialty Chemicals
trans-2,5-Difluorocinnamic acid 98%
5g
$ 125.00

Crysdot
(E)-3-(2,5-Difluorophenyl)acrylicacid 98%
500g
$ 448.00

Total 50 raw suppliers

Chemical Property of trans-2,5-Difluorocinnamic acid Edit

Chemical Property:

Appearance/Colour:white crystalline powder
Vapor Pressure:0.00204mmHg at 25°C
Melting Point:138-140 °C(lit.)
Boiling Point:278.5°Cat760mmHg
PKA:4.16±0.10(Predicted)
Flash Point:122.2°C
PSA：37.30000
Density:1.379g/cm³
LogP:2.06260
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:184.03358575
Heavy Atom Count:13
Complexity:216

Purity/Quality:

99% ^*data from raw suppliers

trans-2,5-Difluorocinnamic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36-26/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)C=CC(=O)O)F
Isomeric SMILES:C1=CC(=C(C=C1F)/C=C/C(=O)O)F
Uses trans-2,5-Difluorocinnamic acid may be used in chemical synthesis.

Technology Process of trans-2,5-Difluorocinnamic acid

There total 2 articles about trans-2,5-Difluorocinnamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

: 110-89-4
piperidine

: 2646-90-4
2,5-difluorobenzaldehyde

: 112898-33-6
3-(2,5-difluorophenyl)acrylic acid

Guidance literature:: With hydrogenchloride; malonic acid; In pyridine;

Reference yield: 10.0%

: 399-94-0
2-bromo-1,4-difluorobenzene

: 79-10-7
acrylic acid

: 112898-33-6
3-(2,5-difluorophenyl)acrylic acid

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In N,N-dimethyl-formamide; at 145 - 150 ℃; for 6h;