Technology Process of 1H-Isoindole-1,3(2H)-dione,
2-[4-chloro-5-(ethoxymethyl)-2-fluorophenyl]-4,5,6,7-tetrahydro-
There total 8 articles about 1H-Isoindole-1,3(2H)-dione,
2-[4-chloro-5-(ethoxymethyl)-2-fluorophenyl]-4,5,6,7-tetrahydro- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; sodium hydrogencarbonate;
In
acetic acid; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 92 percent / Co(OAc)2*4H2O, Mn(OAc)2*4H2O, tert-butyl peroxide, 48percent HBr, O2 / acetic acid / 3 h / 130 - 160 °C / 15514.4 Torr
2: 83 percent / fuming HNO3, conc. H2SO4 / 0 deg C, 1 h then 50 deg C, 1.5 h
3: 93 percent / B2H6 / tetrahydrofuran / 1.5 h / Heating
4: 68 percent / SnCl2*2H2O / ethanol / 2 h / 70 °C
5: 67 percent / TsOH*H2O / toluene / Heating
6: 2,6-dimethylpyridine / CH2Cl2 / 1 h / 0 °C
7: K2CO3 / CH2Cl2 / 2 h / Ambient temperature
With
2,6-dimethylpyridine; di-tert-butyl peroxide; sulfuric acid; hydrogen bromide; oxygen; nitric acid; cobalt(II) acetate; manganese(II) acetate; potassium carbonate; tin(ll) chloride; diborane;
toluene-4-sulfonic acid;
In
tetrahydrofuran; ethanol; dichloromethane; acetic acid; toluene;
DOI:10.1055/s-1987-28110
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 83 percent / fuming HNO3, conc. H2SO4 / 0 deg C, 1 h then 50 deg C, 1.5 h
2: 93 percent / B2H6 / tetrahydrofuran / 1.5 h / Heating
3: 68 percent / SnCl2*2H2O / ethanol / 2 h / 70 °C
4: 67 percent / TsOH*H2O / toluene / Heating
5: 2,6-dimethylpyridine / CH2Cl2 / 1 h / 0 °C
6: K2CO3 / CH2Cl2 / 2 h / Ambient temperature
With
2,6-dimethylpyridine; sulfuric acid; nitric acid; potassium carbonate; tin(ll) chloride; diborane;
toluene-4-sulfonic acid;
In
tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1055/s-1987-28110