Thymidine, 5'-[2-(2,4-dinitrophenyl)ethyl carbonate] 3'-[2-(4-nitrophenyl)ethyl carbonate]

Base Information

• Chemical Name: Thymidine, 5'-[2-(2,4-dinitrophenyl)ethyl carbonate] 3'-[2-(4-nitrophenyl)ethyl carbonate]
• CAS No.: 112138-21-3
• Molecular Formula: C28H27N5O15
• Molecular Weight: 673.547
• Mol file: 112138-21-3.mol

Synonyms:

Chemical Property of Thymidine, 5'-[2-(2,4-dinitrophenyl)ethyl carbonate] 3'-[2-(4-nitrophenyl)ethyl carbonate]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thymidine, 5'-[2-(2,4-dinitrophenyl)ethyl carbonate] 3'-[2-(4-nitrophenyl)ethyl carbonate]

There total 4 articles about Thymidine, 5'-[2-(2,4-dinitrophenyl)ethyl carbonate] 3'-[2-(4-nitrophenyl)ethyl carbonate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(2,4-dinitrophenyl)ethyl chloroformate (111234-22-1) + 3'-O-<2-(4-nitrophenyl)ethoxycarbonyl>thymidine (112141-37-4) → 5'-O-<2-(2,4-dinitrophenyl)ethoxycarbonyl>-3'-O-<2-(4-nitrophenyl)ethoxycarbonyl>thymidine (112138-21-3)

Guidance literature:

With pyridine; In dichloromethane; for 6h; Ambient temperature;

DOI:10.1002/hlca.19930760122

Reference yield: 10.0%

2-(4-nitrophenyl)ethoxycarbonyl chloride (88091-68-3) + 5'-O-[2-(2,4-dinitrophenyl)ethoxycarbonyl]thymidine (111244-91-8) → 5'-O-<2-(2,4-dinitrophenyl)ethoxycarbonyl>-3'-O-<2-(4-nitrophenyl)ethoxycarbonyl>thymidine (112138-21-3) + 5'-O-<2-(2,4-dinitrophenyl)ethoxycarbonyl>-N3,3'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>thymidine

Guidance literature:

With pyridine; In dichloromethane; for 23h; Ambient temperature;

DOI:10.1002/hlca.19930760122

Reference yield:

β-(2,4-dinitrophenyl)ethyl alcohol (4836-69-5) → 5'-O-<2-(2,4-dinitrophenyl)ethoxycarbonyl>-3'-O-<2-(4-nitrophenyl)ethoxycarbonyl>thymidine (112138-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / toluene / 4 h / Ambient temperature

2: 76 percent / pyridine / CH₂Cl₂ / 6 h / Ambient temperature

With pyridine; In dichloromethane; toluene;

DOI:10.1002/hlca.19930760122

upstream raw materials:

2-(4-nitrophenyl)ethoxycarbonyl chloride

5'-O-[2-(2,4-dinitrophenyl)ethoxycarbonyl]thymidine

2-(2,4-dinitrophenyl)ethyl chloroformate

3'-O-<2-(4-nitrophenyl)ethoxycarbonyl>thymidine

Downstream raw materials:

3'-O-<2-(4-nitrophenyl)ethoxycarbonyl>thymidine

Refernces