3-(carboxymethyl)pentanedioic acid

Base Information

• Chemical Name: 3-(carboxymethyl)pentanedioic acid
• CAS No.: 57056-39-0
• Molecular Formula: C7H10 O6
• Molecular Weight: 190.153
• Mol file: 57056-39-0.mol

Synonyms:Glutaricacid, 3-(carboxymethyl)- (6CI,7CI); Methanetriacetic acid; NSC 23786

Chemical Property of 3-(carboxymethyl)pentanedioic acid

Chemical Property:

• Vapor Pressure: 1.84E-06mmHg at 25°C
• Melting Point: 127-128oC
• Boiling Point: 369.2°Cat760mmHg
• PKA: 3.86±0.10(Predicted)
• Flash Point: 191.3°C
• PSA: 111.90000
• Density: 1.481g/cm³
• LogP: 0.02670

Purity/Quality:

99%, ^*data from raw suppliers

3-(carboxymethyl)pentanedioicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(carboxymethyl)pentanedioic acid

There total 1 articles about 3-(carboxymethyl)pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl glutaconate (5164-76-1) → 3-carboxymethylglutaric acid (57056-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / CH₃ONa / methanol / Heating

2: 70 percent / HCl / H₂O / 12 h / Heating

With hydrogenchloride; sodium methylate; In methanol; water;

DOI:10.1070/MC2005v015n05ABEH002164

Reference yield: 88.0%

3-carboxymethylglutaric acid (57056-39-0) + 2-(1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-oxazole-4-carboxylic acid benzyl ester (440369-72-2) → 3-[2-(4-benzyloxycarbonyl-oxazol-2-yl)-2-tert-butoxycarbonylamino-ethoxycarbonylmethyl]-pentanedioic acid bis-[2-(4-benzyloxycarbonyl-oxazol-2-yl)-2-tert-butoxycarbonylamino-ethyl] ester (440369-83-5)

Guidance literature:

With 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 12h;

DOI:10.1016/S0040-4039(02)00284-8

Reference yield: 87.0%

3-carboxymethylglutaric acid (57056-39-0) + 2-((S)-4-Amino-1-benzyloxycarbonylamino-butyl)-thiazole-4-carboxylic acid ethyl ester; hydrochloride → C61H73N9O15S3 (440369-76-6)

Guidance literature:

With pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h;

DOI:10.1016/S0040-4039(02)00284-8

upstream raw materials:

dimethyl glutaconate

Downstream raw materials:

2-(tetrahydropyran-4-yl)-ethanol

(2,6-dioxopiperidin-4-yl)acetic acid

N-(3,4-dimethoxy-phenethyl)-3-[(3,4-dimethoxy-phenethylcarbamoyl)-methyl]-glutaramic acid

N-phenyl-4-carboxymethyl-2,6-piperidinedione

Refernces