2-Furanacetamide, N-phenyl-

Base Information

• Chemical Name: 2-Furanacetamide, N-phenyl-
• CAS No.: 113986-24-6
• Molecular Formula: C12H11NO2
• Molecular Weight: 201.225
• Mol file: 113986-24-6.mol

Synonyms:

Chemical Property of 2-Furanacetamide, N-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Furanacetamide, N-phenyl-

There total 12 articles about 2-Furanacetamide, N-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

furfural tosylhydrazone (18708-18-4) + carbon monoxide (201230-82-2) + aniline (62-53-3) → 2-(furan-2-yl)-N-phenylacetamide (113986-24-6)

Guidance literature:

furfural tosylhydrazone; With sodium hydride; In toluene; mineral oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

carbon monoxide; aniline; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Aliquat (at)366; potassium carbonate; In toluene; mineral oil; at 60 ℃; for 25h; under 760.051 Torr;

DOI:10.1021/ja107351d

Reference yield:

2-(furan-2-yl)acetonitrile (2745-25-7) → 2-(furan-2-yl)-N-phenylacetamide (113986-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous alkaline solution

With alkaline solution;

DOI:10.1021/ja01366a077

Reference yield:

furan-2-yl-acetaldehyde oxime (15854-29-2) → 2-(furan-2-yl)-N-phenylacetamide (113986-24-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid anhydride

2: aqueous alkaline solution

With alkaline solution; acetic anhydride;

DOI:10.1021/ja01366a077

upstream raw materials:

2-(furan-2-yl)acetic acid chloride

aniline

furan-2-yl-acetic acid

2-(furan-2-yl)acetonitrile

Refernces

• 1、 Zhang, Zhenhua,Liu, Yiyang,Ling, Lin,Li, Yuxue,Dong, Yian,Gong, Mingxing,Zhao, Xiaokun,Zhang, Yan,Wang, Jianbo. "Pd-catalyzed carbonylation of diazo compounds at atmospheric pressure: A catalytic approach to ketenes". supporting information; experimental part. p. 4330 - 4341. Retrieved 2011/06/21.