2-Furylacetyl chloride

Base Information

• Chemical Name: 2-Furylacetyl chloride
• CAS No.: 2745-27-9
• Molecular Formula: C6H5 Cl O2
• Molecular Weight: 144.558
• Hs Code.: 2932190090
• European Community (EC) Number: 220-381-9
• DSSTox Substance ID: DTXSID20181865
• Nikkaji Number: J299.207H
• Wikidata: Q83052498
• Mol file: 2745-27-9.mol

Synonyms:Furan-2-acetyl chloride;2-Furylacetyl chloride;2745-27-9;2-(furan-2-yl)acetyl chloride;EINECS 220-381-9;2-furyl acetyl chloride;2-(furan-2-yl)acetylchloride;SCHEMBL1496470;DTXSID20181865;MFCD12196526;EN300-1273109

Chemical Property of 2-Furylacetyl chloride

Chemical Property:

• Vapor Pressure: 0.645mmHg at 25°C
• Boiling Point: 187°Cat760mmHg
• Flash Point: 66.9°C
• PSA: 30.21000
• Density: 1.273g/cm³
• LogP: 1.58750
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 143.9978071
• Heavy Atom Count: 9
• Complexity: 114

Purity/Quality:

98%Min ^*data from raw suppliers

2-Furanacetylchloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)CC(=O)Cl

Technology Process of 2-Furylacetyl chloride

There total 9 articles about 2-Furylacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

furan-2-yl-acetic acid (2745-26-8) → 2-(furan-2-yl)acetic acid chloride (2745-27-9)

Guidance literature:

With thionyl chloride; for 4h; Heating; Inert atmosphere;

Reference yield:

ethyl 2-furanacetate (4915-21-3) → 2-(furan-2-yl)acetic acid chloride (2745-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 18 h / 20 °C / Inert atmosphere

2: thionyl chloride / 4 h / Heating; Inert atmosphere

With thionyl chloride; sodium hydroxide; In ethanol;

Reference yield:

2-Chloromethylfuran (617-88-9) → 2-(furan-2-yl)acetic acid chloride (2745-27-9)

Guidance literature:

Multi-step reaction with 3 steps

1: water

2: methanol. alkaline solution

3: thionyl chloride

With thionyl chloride; alkaline solution; water;

upstream raw materials:

furan-2-yl-acetic acid

2-(furan-2-yl)acetaldehyde

2-Chloromethylfuran

(2-furyl)methyl alcohol

Downstream raw materials:

2-(furan-2-yl)-N-phenylacetamide

3-(2-furyl)propanoic acid

2-(furan-2-yl)-N-methyl-N-phenylpropanamide

Refernces

• 1、 -. "CIBALACKROT RED DYE COMPOUNDS AND METHODS OF USE IN ORGANIC SOLID-STATE LASERS AND OPTO-ELECTRONIC APPLICATIONS". Paragraph 00206. . Retrieved 2021/04/10.
• 2、 Dey, Chandan,Larionov, Evgeny,Kuendig, E. Peter. "Copper(ii) chloride mediated (aza)oxindole synthesis by oxidative coupling of Csp2-H and Csp3-H centers: Substrate scope and DFT study". supporting information. p. 6734 - 6743. Retrieved 2013/10/01.