Ethyl 2-(furan-2-yl)acetate

Base Information

• Chemical Name: Ethyl 2-(furan-2-yl)acetate
• CAS No.: 4915-21-3
• Molecular Formula: C8H10 O3
• Molecular Weight: 154.166
• European Community (EC) Number: 830-822-2
• Nikkaji Number: J511.831J
• Mol file: 4915-21-3.mol

Synonyms:ethyl 2-(furan-2-yl)acetate;ethyl 2-furylacetate;ethyl furyl-acetate;ethyl furan-2-ylacetate;ethyl2-(furan-2-yl)acetate;SCHEMBL1645027;HZCXBPTUYRYPPT-UHFFFAOYSA-N;furan-2-yl-acetic acid ethyl ester;AKOS013262934;EN300-126010

Chemical Property of Ethyl 2-(furan-2-yl)acetate

Chemical Property:

• Refractive Index: 1.4571 (estimate)
• Boiling Point: 237.52°C (rough estimate)
• PSA: 39.44000
• Density: 1.0763
• LogP: 1.85590
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 154.062994177
• Heavy Atom Count: 11
• Complexity: 133

Purity/Quality:

97% ^*data from raw suppliers

ethyl2-(furan-2-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CC1=CC=CO1

Technology Process of Ethyl 2-(furan-2-yl)acetate

There total 27 articles about Ethyl 2-(furan-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl (2E,4E)-3-ethoxy-6-hydroxylhexa-2,4-dienoate (172508-57-5) → ethyl 2-furanacetate (4915-21-3)

Guidance literature:

With hydrogen bromide; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/0040-4039(95)01612-L

Reference yield: 100.0%

2-(E)-(Ethoxycarbonylmethylidene)-4-methoxytetrahydrofuran (350023-89-1) → ethyl 2-furanacetate (4915-21-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1002/ejoc.200400805

Reference yield: 96.0%

furan (110-00-9) + ethyl iodoacetae (623-48-3) → ethyl 2-furanacetate (4915-21-3)

Guidance literature:

With ferrous(II) sulfate heptahydrate; dihydrogen peroxide; In water; dimethyl sulfoxide; at -10 - 20 ℃; for 20h; Inert atmosphere;

upstream raw materials:

diazomethane

2-furanoic acid

furan-2-yl-acetic acid

ethanol

Downstream raw materials:

2-(furan-2-yl)acetic acid chloride

furan-2-yl-acetic acid

1-furan-2-yl-2-(toluene-4-sulfonyloxy)-ethane

3-((1S,2R,3S,4R)-3-Formyl-bicyclo[2.2.1]hept-5-en-2-yl)-3-oxo-propionic acid ethyl ester

Refernces

• 1、 Baciocchi,Muraglia. "Homolytic aromatic substitutions of pentatomic heteroaromatics with electrophilic carbon radicals generated by alkyl halides and triethylborane". . p. 5015 - 5018. Retrieved 1993.
• 2、 -. "CIBALACKROT RED DYE COMPOUNDS AND METHODS OF USE IN ORGANIC SOLID-STATE LASERS AND OPTO-ELECTRONIC APPLICATIONS". Paragraph 00204. . Retrieved 2021/04/10.
• 3、 Schoenauer, Sebastian,Schieberle, Peter. "Structure-Odor Correlations in Homologous Series of Mercapto Furans and Mercapto Thiophenes Synthesized by Changing the Structural Motifs of the Key Coffee Odorant Furan-2-ylmethanethiol". . p. 4189 - 4199. Retrieved 2018/05/01.