3-Isoxazolecarboxylic acid, 5-methyl-, 2-[[(4-bromophenyl)amino]thioxomethyl]hydrazide

Base Information

• Chemical Name: 3-Isoxazolecarboxylic acid, 5-methyl-, 2-[[(4-bromophenyl)amino]thioxomethyl]hydrazide
• CAS No.: 114461-16-4
• Molecular Formula: C₁₂H₁₁BrN₄O₂S
• Molecular Weight: 355.215
• Mol file: 114461-16-4.mol

Synonyms:

Chemical Property of 3-Isoxazolecarboxylic acid, 5-methyl-, 2-[[(4-bromophenyl)amino]thioxomethyl]hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Isoxazolecarboxylic acid, 5-methyl-, 2-[[(4-bromophenyl)amino]thioxomethyl]hydrazide

There total 1 articles about 3-Isoxazolecarboxylic acid, 5-methyl-, 2-[[(4-bromophenyl)amino]thioxomethyl]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methylisoxazole-3-carboxylic acid hydrazide (62438-03-3) + 4-Bromophenyl isothiocyanate (1985-12-2) → C12H11BrN4O2S (114461-16-4)

Guidance literature:

In ethanol;

DOI:10.1002/jccs.200700115

Reference yield:

C12H11BrN4O2S (114461-16-4) → C45H33BrN8OS (1029889-45-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. K₂CO₃

2.1: K₂CO₃ / acetone / 2 h / Heating

2.2: 72 percent / acetone / Heating

With potassium carbonate; In acetone;

DOI:10.1002/jccs.200700115

Reference yield:

C12H11BrN4O2S (114461-16-4) → C26H19BrN8OS

Guidance literature:

Multi-step reaction with 3 steps

1.1: aq. K₂CO₃

2.1: K₂CO₃ / acetone / 2 h / Heating

2.2: 72 percent / acetone / Heating

3.1: 90 percent / aq. HCl / tetrahydrofuran; methanol / 8 h / 20 °C

With hydrogenchloride; potassium carbonate; In tetrahydrofuran; methanol; acetone;

DOI:10.1002/jccs.200700115

upstream raw materials:

5-methylisoxazole-3-carboxylic acid hydrazide

4-Bromophenyl isothiocyanate

Downstream raw materials:

C₁₂H₉BrN₄OS

C₄₅H₃₃BrN₈OS

Refernces