4-(4-Hydroxybenzoyl)-2-thiophenesulfonamide

Base Information Edit

Chemical Name:4-(4-Hydroxybenzoyl)-2-thiophenesulfonamide
CAS No.:118993-57-0
Molecular Formula:C11H9NO4S2
Molecular Weight:283.32300
Hs Code.:
ChEMBL ID:CHEMBL125102
DSSTox Substance ID:DTXSID40872203
Nikkaji Number:J277.486K
Mol file:118993-57-0.mol

Synonyms:118993-57-0;4-(4-Hydroxybenzoyl)-2-thiophenesulfonamide;4-(4-hydroxybenzoyl)thiophene-2-sulfonamide;CHEMBL125102;SCHEMBL10368300;DTXSID40872203

Suppliers and Price of 4-(4-Hydroxybenzoyl)-2-thiophenesulfonamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4-(4-Hydroxybenzoyl)-2-thiophenesulfonamide Edit

Chemical Property:

PSA：134.08000
LogP:3.11320
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:282.99730012
Heavy Atom Count:18
Complexity:409

Purity/Quality:: 95+% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=O)C2=CSC(=C2)S(=O)(=O)N)O

Technology Process of 4-(4-Hydroxybenzoyl)-2-thiophenesulfonamide

There total 5 articles about 4-(4-Hydroxybenzoyl)-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 118976-97-9
4-(4-Methoxybenzoyl)thiophene-2-sulfonamide

: 118993-57-0
4-(4-hydroxybenzoyl)thiophene-2-sulfonamide

Guidance literature:: With hydrogen bromide; for 8h; Heating;
DOI:10.1002/jhet.5570260648

Reference yield:

: 5064-00-6
(4-methoxyphenyl)(thiophen-3-yl)methanone

: 118993-57-0
4-(4-hydroxybenzoyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂SO₄, acetic anhydride / CH₂Cl₂ / 16 h / Ambient temperature

2: thionyl chloride / 1.5 h / Heating

3: ammonium hydroxide / acetone / 0 - 10 °C

4: 74 percent / 48percent aq. HBr / 8 h / Heating

With ammonium hydroxide; thionyl chloride; sulfuric acid; hydrogen bromide; acetic anhydride; In dichloromethane; acetone;
DOI:10.1021/jm00099a010

Reference yield:

: 143509-75-5
4-(4-Methoxy-benzoyl)-thiophene-2-sulfonyl chloride

: 118993-57-0
4-(4-hydroxybenzoyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / acetone / 0 - 10 °C

2: 74 percent / 48percent aq. HBr / 8 h / Heating

With ammonium hydroxide; hydrogen bromide; In acetone;
DOI:10.1021/jm00099a010