Phosphoric acid, 3-hydroxybutyl bis(phenylmethyl) ester

Base Information

• Chemical Name: Phosphoric acid, 3-hydroxybutyl bis(phenylmethyl) ester
• CAS No.: 123417-01-6
• Molecular Formula: C18H23O5P
• Molecular Weight: 350.351
• Mol file: 123417-01-6.mol

Synonyms:

Chemical Property of Phosphoric acid, 3-hydroxybutyl bis(phenylmethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid, 3-hydroxybutyl bis(phenylmethyl) ester

There total 7 articles about Phosphoric acid, 3-hydroxybutyl bis(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1.3-butanediol (18826-95-4,107-88-0) + dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate (990-91-0) → 3-(dibenzyl)phosphoryloxy-1-methyl-1-propanol (123417-01-6)

Guidance literature:

With tetrahexylammonium iodide; silver(l) oxide; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1016/j.tetlet.2005.05.127

Reference yield: 65.0%

1.3-butanediol (18826-95-4,107-88-0) + tribenzyl phosphite (15205-57-9) → dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate (990-91-0) + dibenzyl hydrogen phosphite (538-60-3) + 3-(dibenzyl)phosphoryloxy-1-methyl-1-propanol (123417-01-6)

Guidance literature:

tribenzyl phosphite; With iodine; In dichloromethane; at 0 - 20 ℃; for 0.416667h;

1.3-butanediol; With pyridine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1080/10426500108040232

Reference yield: 53.0%

1.3-butanediol (18826-95-4,107-88-0) + dibenzyl phosphorofluoridate (123417-05-0) → 3-(dibenzyl)phosphoryloxy-1-methyl-1-propanol (123417-01-6)

Guidance literature:

With cesium fluoride; In acetonitrile; for 20h; Ambient temperature;

DOI:10.1016/S0040-4039(00)82184-X

upstream raw materials:

1.3-butanediol

dibenzyl phosphorofluoridate

tribenzyl phosphite

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

Refernces

• 1、 Takeda, Shuzo,Chino, Masao,Kiuchi, Masatoshi,Adachi, Kunitomo. "Direct mono-phosphorylation of 1,3-diols. A synthesis of FTY720-phosphate". . p. 5169 - 5172. Retrieved 2005.
• 2、 Coppola, Kyle A.,Testa, Joseph W.,Allen, Emily E.,Sculimbrene, Bianca R.. "Selective phosphorylation of diols with a Lewis acid catalyst". supporting information. p. 4203 - 4206. Retrieved 2015/02/02.