4,6-Dichloropicolinaldehyde

Base Information

• Chemical Name: 4,6-Dichloropicolinaldehyde
• CAS No.: 132683-62-6
• Molecular Formula: C6H3Cl2NO
• Molecular Weight: 176.002
• European Community (EC) Number: 879-237-4
• Mol file: 132683-62-6.mol

Synonyms:4,6-DICHLOROPICOLINALDEHYDE;132683-62-6;2-Pyridinecarboxaldehyde, 4,6-dichloro-;4,6-DICHLOROPYRIDINE-2-CARBALDEHYDE;2-Formyl-4,6-dichloropyridin;4,6-Dichloro-pyridine-2-carbaldehyde;2-Formyl-4,6-dichloropyridine;SCHEMBL1572837;VNSCIAVHRDIZMI-UHFFFAOYSA-N;MFCD10698614;AKOS022709412;AB62517;DS-10445;CS-0145986;C72313;EN300-1725450

Chemical Property of 4,6-Dichloropicolinaldehyde

Chemical Property:

• PSA: 29.96000
• LogP: 2.20090
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 174.9591691
• Heavy Atom Count: 10
• Complexity: 131

Purity/Quality:

98%min ^*data from raw suppliers

4,6-Dichloropicolinaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(N=C1C=O)Cl)Cl

Technology Process of 4,6-Dichloropicolinaldehyde

There total 6 articles about 4,6-Dichloropicolinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.4%

(4,6-dichloropyridin-2-yl)methanol (856163-79-6) → 2,4-dichloropyridine-2-carbaldehyde (132683-62-6)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield: 53.0%

2,4-dichloro-6-(dibromomethyl)pyridine → 2,4-dichloropyridine-2-carbaldehyde (132683-62-6)

Guidance literature:

With silver nitrate; In ethanol; water; for 8h; Reflux;

Reference yield:

methyl 4,6-dichloropyridine-2-carboxylate (98273-19-9) → 2,4-dichloropyridine-2-carbaldehyde (132683-62-6)

Guidance literature:

With ammonium chloride; diisobutylaluminium hydride; In water; toluene;

upstream raw materials:

4,6-dichloro-pyridine-2-carbonyl chloride

methyl 4,6-dichloropyridine-2-carboxylate

2,4-dichloro-6-methyl-pyridine

(4,6-dichloropyridin-2-yl)methanol

Downstream raw materials:

(4,6-dichloropyridin-2-yl)methanol

Refernces

• 1、 -. "As neuroprotective agents of pharmaceutical compounds". Paragraph 0048; 0449; 0452; 0453; 0461. . Retrieved 2019/06/26.
• 2、 -. "Heteroarylethanol-pyridylalkylamines for controlling animal growth". . . Retrieved 2008/06/13.