2,2-Bis(4-methoxyphenyl)acetic acid

Base Information

• Chemical Name: 2,2-Bis(4-methoxyphenyl)acetic acid
• CAS No.: 4541-73-5
• Molecular Formula: C16H16O4
• Molecular Weight: 272.301
• NSC Number: 12025
• DSSTox Substance ID: DTXSID90196507
• Nikkaji Number: J1.868.734H
• Wikidata: Q83069548
• Mol file: 4541-73-5.mol

Synonyms:2,2-bis(4-methoxyphenyl)acetic acid;4541-73-5;4-Methoxy-alpha-(4-methoxyphenyl)benzeneacetic acid;Benzeneacetic acid, 4-methoxy-alpha-(4-methoxyphenyl)-;Benzeneacetic acid,4-methoxy-alpha-(4-methoxyphenyl)-;NSC12025;SCHEMBL7044804;DTXSID90196507;LZASYCDJCJCVCW-UHFFFAOYSA-N;bis-(4-methoxyphenyl)-acetic acid;NSC 12025;NSC-12025

Chemical Property of 2,2-Bis(4-methoxyphenyl)acetic acid

Chemical Property:

• Vapor Pressure: 3.38E-08mmHg at 25°C
• Boiling Point: 431.1°Cat760mmHg
• Flash Point: 158.7°C
• Density: 1.19g/cm³
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 272.10485899
• Heavy Atom Count: 20
• Complexity: 278

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)C(=O)O

Technology Process of 2,2-Bis(4-methoxyphenyl)acetic acid

There total 16 articles about 2,2-Bis(4-methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-Methoxyphenylacetic acid (104-01-8) + 1-bromo-4-methoxy-benzene (104-92-7) → 2,2-bis-(4-methoxyphenyl)acetic acid (4541-73-5)

Guidance literature:

4-Methoxyphenylacetic acid; With tert-butylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

1-bromo-4-methoxy-benzene; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos; In tetrahydrofuran; at 60 ℃; for 3h; Reagent/catalyst; Inert atmosphere;

DOI:10.1002/ejoc.201402450

Reference yield: 94.0%

methoxybenzene (100-66-3) + Glyoxilic acid (298-12-4) → 2,2-bis-(4-methoxyphenyl)acetic acid (4541-73-5)

Guidance literature:

With acetic acid; at 60 ℃; for 4h; Solvent; Reagent/catalyst;

DOI:10.1080/00397911.2016.1158269

Reference yield: 70.0%

2,4,6-trimethylmandelic acid (20797-56-2) + methoxybenzene (100-66-3) → 2,2-bis-(4-methoxyphenyl)acetic acid (4541-73-5)

Guidance literature:

With tin(IV) chloride; at 70 ℃; for 8h;

DOI:10.1021/jo00257a033

upstream raw materials:

1,1-dichloro-2,2-bis(p-methoxyphenyl)ethylene

2,2-bis(4-methoxyphenyl)acetonitrile

methoxybenzene

butyl glyoxalate

Downstream raw materials:

Bis(4-methoxyphenyl)essigsaeurechlorid

2,2-bis (4-hydroxyphenyl)acetic acid

ethyl 2,2-bis(4-methoxyphenyl)acetate

bis(p-methoxyphenyl)methanone

Refernces

• 1、 Zhou, Xiaorong,Peng, Zhixing,Zhao, Hongyang,Zhang, Zhiyin,Lu, Ping,Wang, Yanguang. "Rh-Catalyzed annulations of: N -methoxybenzamides with ketenimines: Synthesis of 3-aminoisoindolinones and 3-diarylmethyleneisoindolinones with strong aggregation induced emission properties". supporting information. p. 10676 - 10679. Retrieved 2016/09/02.
• 2、 -. "Nucleic acids encoding microsomal trigyceride transfer protein". . . Retrieved 2008/06/13.