[1,1'-Biphenyl]-4-amine, 3,5-dichloro-

Base Information

• Chemical Name: [1,1'-Biphenyl]-4-amine, 3,5-dichloro-
• CAS No.: 134006-32-9
• Molecular Formula: C₁₂H₉Cl₂N
• Molecular Weight: 238.116
• Mol file: 134006-32-9.mol

Synonyms:

Chemical Property of [1,1'-Biphenyl]-4-amine, 3,5-dichloro-

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99%min. ^*data from raw suppliers

2,6-Dichloro-4-phenylaniline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1,1'-Biphenyl]-4-amine, 3,5-dichloro-

There total 3 articles about [1,1'-Biphenyl]-4-amine, 3,5-dichloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

3,5-di-tert-butylbiphenyl-4-ylamine (65624-10-4) → 3,5-dichlorobiphenyl-4-ylamine (134006-32-9)

Guidance literature:

With tetraethylammonium chloride; sodium carbonate; In acetonitrile; anodic oxidation in CH₃CN, Pt-electrode potential: +1.0 V vs SCE;

DOI:10.1021/jo00015a019

Reference yield:

2,6-dichloro-4-iodoaniline (697-89-2) + phenylboronic acid (98-80-6) → 3,5-dichlorobiphenyl-4-ylamine (134006-32-9)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; for 24h; Heating / reflux;

Reference yield:

4-bromo-2,6-dichloroaniline (697-88-1) + phenylboronic acid (98-80-6) → 3,5-dichlorobiphenyl-4-ylamine (134006-32-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In diethyl ether; water; toluene; at 100 ℃; for 5h; Inert atmosphere;

upstream raw materials:

3,5-di-tert-butylbiphenyl-4-ylamine

2,6-dichloro-4-iodoaniline

phenylboronic acid

4-bromo-2,6-dichloroaniline

Refernces

• 1、 -. "SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS". Page 25-26. . Retrieved 2008/06/13.