2,6-Dichloro-4-iodoaniline

Base Information

• Chemical Name: 2,6-Dichloro-4-iodoaniline
• CAS No.: 697-89-2
• Molecular Formula: C6H4Cl2IN
• Molecular Weight: 287.915
• Hs Code.: 2921420090
• DSSTox Substance ID: DTXSID20219990
• Nikkaji Number: J55.216J
• Wikidata: Q83097049
• Mol file: 697-89-2.mol

Synonyms:2,6-Dichloro-4-iodoaniline;697-89-2;BRN 2718196;ANILINE, 2,6-DICHLORO-4-IODO-;Benzenamine,2,6-dichloro-4-iodo-;C6H4Cl2IN;C6-H4-Cl2-I-N;SCHEMBL2861514;DTXSID20219990;Benzenamine, 2,6-dichloro-4-iodo-;MFCD01670182;AKOS016016194;AT25401;SB82295;LS-19695

Chemical Property of 2,6-Dichloro-4-iodoaniline

Chemical Property:

• Vapor Pressure: 0.00166mmHg at 25°C
• Refractive Index: 1.699
• Boiling Point: 294 °C at 760 mmHg
• Flash Point: 131.6 °C
• PSA: 26.02000
• Density: 2.091 g/cm³
• LogP: 3.76140
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 286.87655
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dichloro-4-iodoaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1Cl)N)Cl)I

Technology Process of 2,6-Dichloro-4-iodoaniline

There total 2 articles about 2,6-Dichloro-4-iodoaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,6-Dichloroaniline (608-31-1) → 2,6-dichloro-4-iodoaniline (697-89-2)

Guidance literature:

With pyridinium iodochloride; In methanol; for 1h; Heating;

DOI:10.1080/00397910801989659

Reference yield:

→ 2,6-dichloro-4-iodoaniline (697-89-2)

Guidance literature:

Aus 2,6-Dichlor-anilin, Iod-monochlorid in Eg., Erh.;

Reference yield: 79.0%

2,6-dichloro-4-iodoaniline (697-89-2) + 9-methyl-9H-fluorene-9-carbonyl chloride (82102-37-2) → 4-Amino-3,5-dichlorobenzaldehyde (62909-66-4)

Guidance literature:

With dichloro(1,5-cyclooctadiene)palladium(II); N-Methyldicyclohexylamine; potassium formate; tetra-(n-butyl)ammonium iodide; tricyclohexylphosphine tetrafluoroborate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In acetonitrile; at 80 ℃; for 18h; Sealed tube; Glovebox; Inert atmosphere;

DOI:10.1021/jo400741t

upstream raw materials:

2,6-Dichloroaniline

Downstream raw materials:

1-benzoyl-3-(2,6-dichloro-4-iodophenyl)thiourea

(6-chloro-2-methyl-pyrimidin-4-yl)-(2,6-dichloro-4-iodo-phenyl)-amine

N-cyclopropylmethyl-N'-(2,6-dichloro-4-iodo-phenyl)-2-methyl-N-propyl-pyrimidine-4,6-diamine

3,5-dichlorobiphenyl-4-ylamine

Refernces

• 1、 Shinde, Avinash T.,Zangade, Sainath B.,Chavan, Shivaji B.,Vibhute, Archana Y.,Nalwar, Yogesh S.,Vibhute, Yeshwant B.. "A practical iodination of aromatic compounds by using iodine and iodic acid". experimental part. p. 3506 - 3513. Retrieved 2011/02/22.
• 2、 Reddy, K. Suresh Kumar,Narender,Rohitha,Kulkarni. "Iodination of aromatic compounds using potassium iodide and hydrogen peroxide". experimental part. p. 3894 - 3902. Retrieved 2009/04/04.