62909-66-4 Usage
Description
4-Amino-3,5-dichlorobenzaldehyde is an organic compound characterized by its aldehyde group and two chlorine atoms attached to the benzene ring. It is known for its potential applications in the pharmaceutical and chemical industries due to its unique chemical structure and reactivity.
Uses
Used in Pharmaceutical Industry:
4-Amino-3,5-dichlorobenzaldehyde is used as a reagent for the synthesis of pyrazolopyridine derivatives, which serve as inhibitors of phosphodiesterase-4 (PDE-IV). These inhibitors play a crucial role in modulating the inflammatory response and are being investigated for their potential therapeutic applications in treating various diseases, including chronic obstructive pulmonary disease (COPD) and asthma.
Additionally, 4-Amino-3,5-dichlorobenzaldehyde is utilized in the production of tumor necrosis factor-α (TNF-α), a cytokine involved in systemic inflammation and immune responses. Modulating TNF-α levels can be beneficial in treating autoimmune diseases and certain cancers.
Used in Chemical Synthesis:
4-Amino-3,5-dichlorobenzaldehyde is also employed as a reagent in the synthesis of amino acid derivatives, which act as neuropeptide Y antagonists. These antagonists have potential applications in the treatment of various conditions, such as obesity, anxiety, and depression, by modulating the neuropeptide Y system.
Furthermore, 4-Amino-3,5-dichlorobenzaldehyde is recognized as an impurity in Clenbuterol (C569998, HCl), a medication used for treating asthma and other respiratory conditions. Its presence in the synthesis process highlights the importance of controlling the purity of active pharmaceutical ingredients to ensure the safety and efficacy of the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 62909-66-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,9,0 and 9 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 62909-66:
(7*6)+(6*2)+(5*9)+(4*0)+(3*9)+(2*6)+(1*6)=144
144 % 10 = 4
So 62909-66-4 is a valid CAS Registry Number.
62909-66-4Relevant articles and documents
Reductive carbonylation of aryl halides employing a two-chamber reactor: A protocol for the synthesis of aryl aldehydes including 13C- and D-isotope labeling
Korsager, Signe,Taaning, Rolf H.,Lindhardt, Anders T.,Skrydstrup, Troels
, p. 6112 - 6120 (2013/07/26)
A protocol has been developed for conducting the palladium-catalyzed reductive carbonylation of aryl iodides and bromides using 9-methylfluorene-9- carbonyl chloride (COgen) as a source of externally delivered carbon monoxide in a sealed two-chamber system (COware), and potassium formate as the in situ hydride source. The method is tolerant to a wide number of functional groups positioned on the aromatic ring, and it can be exploited for the isotope labeling of the aldehyde group. Hence, reductive carbonylations run with 13COgen provide a facile access to 13C-labeled aromatic aldehydes, whereas with DCO2K, the aldehyde is specifically labeled with deuterium. Two examples of double isotopic labeling are also demonstrated. Finally, the method was applied to the specific carbon-13 labeling of the β-amyloid binding compound, florbetaben.
