78473-00-4

Basic information

• Product Name: 4-Amino-3,5-dichlorobenzonitrile
• Synonyms: BUTTPARK 35\03-66;2,6-DICHLORO-4-CYANOANILINE;4-AMINO-3,5-DICHLOROBENZONITRILE;TIMTEC-BB SBB003696;4-cyano-2,6-dichloroaniline;4-Amino-3,5-dichlorobenzonitrile 98%;4-Amino-3,5-dichlorobenzonitrile,99%;1-aMino-2,6-dichloro-4-cyanobenzene
• CAS NO: 78473-00-4
• Molecular Formula: C₇H₄Cl₂N₂
• Molecular Weight: 187.03
• EINECS: 278-914-6
• Product Categories: Aromatic Nitriles;C6 to C7;Cyanides/Nitriles;Nitrogen Compounds;Building Blocks;C6 to C7;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 78473-00-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 116-120 °C(lit.)
• Boiling Point: 307.58°C (rough estimate)
• Flash Point: 119 °C
• Appearance: white powder
• Density: 1.5159 (rough estimate)
• Vapor Pressure: 0.00581mmHg at 25°C
• Refractive Index: 1.6400 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: -2.17±0.10(Predicted)
• BRN: 2719605
• CAS DataBase Reference: 4-Amino-3,5-dichlorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3,5-dichlorobenzonitrile(78473-00-4)
• EPA Substance Registry System: 4-Amino-3,5-dichlorobenzonitrile(78473-00-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-43-36/37/38
• Safety Statements: 36/37-36/37/39-26-22
• RIDADR: 3276
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 78473-00-4(Hazardous Substances Data)

Usage

Chemical Properties

white powder

InChI:InChI=1/C7H4Cl2N2/c8-5-1-4(3-10)2-6(9)7(5)11/h1-2H,11H2

Upstream product

• 7722-84-1 dihydrogen peroxide 
• 873-74-5 4-Aminobenzonitrile 
• 62909-66-4 4-Amino-3,5-dichlorobenzaldehyde 

Downstream Products

• 98278-87-6 2,6-Dichlor-4-cyano-nitrosobenzol 
• 98278-88-7 3.5-Dichlor-4-nitro-benzonitril 
• 856695-03-9 4-[4-(butyl-ethyl-amino)-6-methyl-3-nitro-pyridin-2-ylamino]-3,5-dichloro-benzonitrile 
• 22134-03-8 3,5-dichloro-4-isothiocyanatobenzonitrile 
• 1173523-58-4 (S)-3,5-dichloro-4-[6-chloro-4-(1-cyclopropylpropyl)-3-oxo-3,4-dihydropyrazin-2-ylamino]benzonitrile 
• 1173523-61-9 (S)-3,5-dichloro-4-(6-chloro-4-(1-cyclopropylethyl)-3-oxo-3,4-dihydropyrazin-2-ylamino)benzonitrile 
• 1173435-54-5 (R)-3,5-dichloro-4-[6-chloro-4-(1-cyclopropylethyl)-3-oxo-3,4-dihydropyrazin-2-ylamino]benzonitrile 
• 1173435-26-1 (R)-3,5-dichloro-4-[6-chloro-4-(1-cyclopropylpropyl)-3-oxo-3,4-dihydropyrazin-2-ylamino]benzonitrile 
• 927676-49-1 4-acetamido-3,5-dichloro-benzonitrile 
• 117757-68-3 3,5-dichloro-4-iodobenzoic acid 

Relevant articles and documents

A practical and cost-efficient, one-pot conversion of aldehydes into nitriles mediated by 'activated DMSO'

Participation of activated DMSO in the one-pot transformation of aldehydes to nitriles has been described by reacting aldehydes with NHHHCl in DMSO in the absence of any added base or catalyst. The method is applicable to access a wide range of aromatic, heterocyclic, and aliphatic nitriles, in which only water is a byproduct. A straightforward and practical procedure is demonstrated on a multigram scale. Georg Thieme Verlag Stuttgart - New York.

USE OF 2-[(3,5-DIHALO-4-AMINOBENZYL)] IMIDAZOLINES TO STIMULATE ALPHA-1 ADRENERGIC RECEPTORS AND TO TREAT NASAL CONGESTION

Disclosed herein are alpha adrenergic and nasal decongestant compounds of the formula STR1 wherein R 1 and R 2, each being the same or different, are halogens, and the pharmaceutically acceptable salts thereof.

Method for lowering intraocular pressure using phenylimino-imidazoles

2-(Trisubstituted phenylimino)-imidazole compounds also known as 2-(trisubstituted anilino)-1,3 diazacyclopentene-(2) compounds are used to lower intraocular pressure.