Ethyl 4,4-difluoroacetoacetate

Base Information Edit

Chemical Name:Ethyl 4,4-difluoroacetoacetate
CAS No.:352-24-9
Molecular Formula:C6H8F2O3
Molecular Weight:166.125
Hs Code.:2918300090
European Community (EC) Number:206-519-0
DSSTox Substance ID:DTXSID2059851
Nikkaji Number:J193.822C
Wikidata:Q72474323
Mol file:352-24-9.mol

Synonyms:ethyl 4,4-difluoro-3-oxobutanoate;352-24-9;Ethyl 4,4-difluoroacetoacetate;Ethyl 4,4-difluoro-3-oxobutyrate;Ethyl difluoroacetoacetate;Butanoic acid, 4,4-difluoro-3-oxo-, ethyl ester;C6H8F2O3;4,4-Difluoroacetoacetic Acid Ethyl Ester;EINECS 206-519-0;MFCD00039277;4,4-difluoro-3-oxo-butyric acid ethyl ester;ethyl 4,4-difluoro-3-oxo-butanoate;SCHEMBL18890;DTXSID2059851;ethyl 4,4-difluoro(acetoacetate);ethyl 4,4-difluoro-3-ketobutyrate;FD2057;STK312810;AKOS000305790;CS-W009248;AM803758;DS-14761;SY016930;4,4-Difluoro-3-oxobutanoic acid ethyl ester;4,4-Difluoro-3-oxobutyric Acid Ethyl Ester;E1018;FT-0601864;4,4-Difluoro-3-oxo butyric acid ethyl ester;4,4-difluoro-3-oxo-butanoic acid ethyl ester;EN300-65605;J-520947;F8888-6294

Suppliers and Price of Ethyl 4,4-difluoroacetoacetate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl 4,4-Difluoroacetoacetate
100g
$ 745.00

TRC
Ethyl 4,4-Difluoroacetoacetate
10g
$ 165.00

TCI Chemical
Ethyl 4,4-Difluoroacetoacetate >96.0%(GC)
25g
$ 87.00

TCI Chemical
Ethyl 4,4-Difluoroacetoacetate >96.0%(GC)
5g
$ 30.00

SynQuest Laboratories
Ethyl 4,4-difluoro-3-oxobutyrate 97%
10 g
$ 20.00

SynQuest Laboratories
Ethyl 4,4-difluoro-3-oxobutyrate 97%
5 g
$ 15.00

SynQuest Laboratories
Ethyl 4,4-difluoro-3-oxobutyrate 97%
25 g
$ 40.00

SynQuest Laboratories
Ethyl 4,4-difluoro-3-oxobutyrate 97%
100 g
$ 105.00

Sigma-Aldrich
Ethyl 4,4-difluoroacetoacetate 98% (mixture of tautomers)
5g
$ 41.30

Sigma-Aldrich
Ethyl 4,4-difluoroacetoacetate 98% (mixture of tautomers)
25g
$ 137.00

Total 121 raw suppliers

Chemical Property of Ethyl 4,4-difluoroacetoacetate Edit

Chemical Property:

Vapor Pressure:1.49mmHg at 25°C
Melting Point:-46°C(lit.)
Refractive Index:1.407
Boiling Point:170.1 °C at 760 mmHg
PKA:8.61±0.46(Predicted)
Flash Point:55.7 °C
Density:1.191 g/cm³
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
XLogP3:1.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:166.04415044
Heavy Atom Count:11
Complexity:156

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 4,4-Difluoroacetoacetate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi; F
Hazard Codes:F,Xi
Statements: 10-36/37/38-36/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC(=O)C(F)F
Uses Ethyl 4,4-difluoro-3-oxobutanoate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists. Ethyl 4,4-Difluoroacetoacetate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.

Technology Process of Ethyl 4,4-difluoroacetoacetate

There total 25 articles about Ethyl 4,4-difluoroacetoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

: 454-31-9
ethyl difluoroacetate

: 141-78-6
ethyl acetate

: 352-24-9
ethyl 4,4-difluoro-3-oxobutyrate

Guidance literature:: ethyl acetate; With sodium ethanolate; at 25 ℃;

ethyl difluoroacetate; at 10 - 65 ℃;

With sulfuric acid; water; at 20 - 25 ℃; for 0.333333h; Product distribution / selectivity;