Ethyl (2E)-4,4-difluorobut-2-enoate

Base Information Edit

Chemical Name:Ethyl (2E)-4,4-difluorobut-2-enoate
CAS No.:37746-82-0
Molecular Formula:C₆H₈F₂O₂
Molecular Weight:150.125
Hs Code.:
European Community (EC) Number:817-534-2,829-494-3
DSSTox Substance ID:DTXSID20581629
Nikkaji Number:J2.285.758D,J2.420.861C
Wikidata:Q76507350
Mol file:37746-82-0.mol

Synonyms:ETHYL (2E)-4,4-DIFLUOROBUT-2-ENOATE;1992-97-8;37746-82-0;ethyl (E)-4,4-difluorobut-2-enoate;4,4-DIFLUORO-BUT-2-ENOIC ACID ETHYL ESTER;ethyl 4,4-difluorobut-2-enoate;(2E)-4,4-Difluoro-2-butenoic acid ethyl ester;(E)-ethyl 4,4-difluorobut-2-enoate;SCHEMBL15927354;DTXSID20581629;MFCD13190452;AKOS040766222;CS-0113942;CS-0369121;4,4-DIFLUORO-BUT-2-ENOICACIDETHYLESTER;EN300-106847;EN300-314791;F2147-8269

Suppliers and Price of Ethyl (2E)-4,4-difluorobut-2-enoate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl(E)-4,4-Difluoro-but-2-enoate
500mg
$ 250.00

Total 3 raw suppliers

Chemical Property of Ethyl (2E)-4,4-difluorobut-2-enoate Edit

Chemical Property:

PSA：26.30000
LogP:1.37080
XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:150.04923582
Heavy Atom Count:10
Complexity:132

Purity/Quality:

99% ^*data from raw suppliers

Ethyl(E)-4,4-Difluoro-but-2-enoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C=CC(F)F
Isomeric SMILES:CCOC(=O)/C=C/C(F)F
Uses Ethyl (E)-4,4-Difluoro-but-2-enoate was used to study a three-step preparation of β-?fluoroalkyl acrylates from fluoroacetic esters.

Technology Process of Ethyl (2E)-4,4-difluorobut-2-enoate

There total 3 articles about Ethyl (2E)-4,4-difluorobut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 145374-00-1
ethyl 4,4-difluoro-3-hydroxy-butanoate

: 37746-82-0,1992-97-8
ethyl (E)-4,4-difluoro-but-2-enoate

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 352-24-9
ethyl 4,4-difluoro-3-oxobutyrate

: 37746-82-0,1992-97-8
ethyl (E)-4,4-difluoro-but-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / sodium borohydride / toluene / 4.5 h / 20 °C

2: phosphorus pentoxide / 1 h

With phosphorus pentaoxide; sodium tetrahydroborate; In toluene;
DOI:10.1016/j.tet.2006.12.045