PHENYL-2-PIPERIDINYL-METHANONE HYDROCHLORIDE

Base Information

• Chemical Name: PHENYL-2-PIPERIDINYL-METHANONE HYDROCHLORIDE
• CAS No.: 138371-65-0
• Molecular Formula: C12H15NO.ClH
• Molecular Weight: 225.71500
• Hs Code.: 2933399090
• Mol file: 138371-65-0.mol

Synonyms:Methanone,phenyl-2-piperidinyl-,hydrochloride;Phenyl-2-piperidinylmethanone HCl;2-benzoylpiperidine hydrochloride;

Chemical Property of PHENYL-2-PIPERIDINYL-METHANONE HYDROCHLORIDE

Chemical Property:

• Melting Point: >215°C (dec.)
• PSA: 29.10000
• LogP: 3.14220
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-BenzoylpiperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PHENYL-2-PIPERIDINYL-METHANONE HYDROCHLORIDE

There total 6 articles about PHENYL-2-PIPERIDINYL-METHANONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,1-dimethylethyl 2-benzoyl-1-piperidinecarboxylate (138371-52-5) → phenyl(2-piperidinyl)methanone hydrochloride (138371-65-0)

Guidance literature:

With hydrogenchloride; In methanol; for 1h; Heating;

DOI:10.1139/v91-298

Reference yield:

hydrogen chloride-ethyl acetate + 6-methoxymethyl-8-phenyl-2,3,4,6-tetrahydropyrido[2,3-d]pyridazin-5(1H)-one (590409-12-4) → phenyl(2-piperidinyl)methanone hydrochloride (138371-65-0)

Guidance literature:

Reference yield:

rac-piperidin-2-yl-phenylmethanone (23702-99-0) → phenyl(2-piperidinyl)methanone hydrochloride (138371-65-0)

Guidance literature:

With hydrogenchloride; In diethyl ether;

DOI:10.1021/acschemneuro.9b00284

upstream raw materials:

1,1-dimethylethyl 2-benzoyl-1-piperidinecarboxylate

pipecolic Acid

benzene

2-aminoacetophenone hydrochloride

Refernces

• 1、 -. "FUSED PYRIDAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT". . . Retrieved 2008/06/13.
• 2、 Guzman,Quintero,Muchowski. "Alkylation of α-tert-butoxycarbonylamino ketone enolate anions. A useful synthesis of α-alkyl-α-amino ketones, 2-acylpyrrolidines, and 2-acylpiperidines". . p. 2059 - 2063. Retrieved 2007/10/02.