NA

Base Information

• Chemical Name: NA
• CAS No.: 23702-99-0
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.257
• Mol file: 23702-99-0.mol

Synonyms:

Chemical Property of NA

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NA

There total 10 articles about NA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

alpha-phenyl-2-piperidinemethanol (23702-98-9) → rac-piperidin-2-yl-phenylmethanone (23702-99-0)

Guidance literature:

With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 0 - 10 ℃; for 1h;

DOI:10.1080/00397911.2017.1293109

Reference yield: 85.0%

(1-(4-methoxyphenyl)piperidin-2-yl)(phenyl)methanone → rac-piperidin-2-yl-phenylmethanone (23702-99-0)

Guidance literature:

With ammonium cerium (IV) nitrate; In water; acetonitrile; at 0 ℃;

DOI:10.1021/acs.orglett.1c00226

Reference yield: 64.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + (±)-7-hydroxy-7-phenyl-1-azabicyclo[4.2.0]octan-8-one (21675-04-7,113397-14-1,113397-15-2,113472-45-0,113472-46-1,131433-14-2) → rac-piperidin-2-yl-phenylmethanone (23702-99-0)

Guidance literature:

With [Rh(OH)(cod)]2; potassium carbonate; triphenylphosphine; In toluene; at 100 ℃; for 20h; Reagent/catalyst; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/jacs.0c04278

upstream raw materials:

benzoic acid

phenyl(pyridin-2-yl)methanone

alpha-phenyl-2-piperidinemethanol

methyl 2-oxo-2-phenylacetate

Downstream raw materials:

(R)-N-(tert-butyloxycarbonyl)piperidin-2-yl-phenylmethanone

(S)-N-(tert-butyloxycarbonyl)piperidin-2-yl-phenylmethanone

phenyl(2-piperidinyl)methanone hydrochloride

2-Benzoyl-1-(3-phenoxypropyl)piperidine

Refernces

• 1、 Ham, Jin Su,Park, Bohyun,Son, Mina,Roque, Jose B.,Jurczyk, Justin,Yeung, Charles S.,Baik, Mu-Hyun,Sarpong, Richmond. "C-H/C-C Functionalization Approach to N-Fused Heterocycles from Saturated Azacycles". . p. 13041 - 13050. Retrieved 2020/09/01.
• 2、 Li, Chunzheng,Ji, Yuanbo,Cao, Qing,Li, Jianqi,Li, Bonan. "Concise and facile synthesis of (R,R)-dexmethylphenidate hydrochloride and its three stereoisomers". . p. 1301 - 1306. Retrieved 2017/07/12.