3-Fluorobenzylamine hydrochoride

Base Information

• Chemical Name: 3-Fluorobenzylamine hydrochoride
• CAS No.: 658-25-3
• Molecular Formula: C7H8FN
• Molecular Weight: 161.607
• Mol file: 658-25-3.mol

Synonyms:3-Fluoro-benzylamine;hydrochloride;3-fluorobenzylamine hydrochloride;

Chemical Property of 3-Fluorobenzylamine hydrochoride

Chemical Property:

• Melting Point: 254 - 256 °C
• Boiling Point: 175.8°Cat760mmHg
• Flash Point: 71.1°C
• PSA: 26.02000
• Density: 1.101g/cm³
• LogP: 2.78670

Purity/Quality:

99% ^*data from raw suppliers

3-Fluorobenzylamine hydrochoride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Fluorobenzylamine hydrochoride

There total 5 articles about 3-Fluorobenzylamine hydrochoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(3-fluorobenzyl)-3,4-diphenyl-1H-pyrrole-2,5-dione (1402844-51-2) → 2,3-diphenylmaleic anhydride (4808-48-4) + (3-fluorophenyl)methanamine hydrochloride (658-25-3)

Guidance literature:

1-(3-fluorobenzyl)-3,4-diphenyl-1H-pyrrole-2,5-dione; With potassium hydroxide; In ethanol; water; at 102 ℃; for 0.133333h; Microwave irradiation; Green chemistry;

With hydrogenchloride; In ethanol; water; pH=4; Temperature; Green chemistry;

DOI:10.1039/c6gc01318j

Reference yield: 81.0%

m-Fluorobenzonitrile (403-54-3) → (3-fluorophenyl)methanamine hydrochloride (658-25-3)

Guidance literature:

m-Fluorobenzonitrile; With borane-ammonia complex; C₁₇H₁₆BrMnN₂O₃S; In hexane; at 60 ℃; for 6h;

With hydrogenchloride; In diethyl ether; water;

DOI:10.1021/acscatal.0c05406

Reference yield:

(3-fluorophenyl)methanamine (100-82-3) → (3-fluorophenyl)methanamine hydrochloride (658-25-3)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃;

DOI:10.1016/j.tet.2020.131439

upstream raw materials:

m-fluorobenzyl chloride

1-(3-fluorobenzyl)-3,4-diphenyl-1H-pyrrole-2,5-dione

(3-fluorophenyl)methanamine

m-Fluorobenzonitrile

Downstream raw materials:

4-chloro-N-(3-fluoro-benzyl)-2-hydroxy-benzamide

Refernces

• 1、 Ganguli, Kasturi,Mandal, Adarsha,Sarkar, Bidisha,Kundu, Sabuj. "Benzimidazole fragment containing Mn-complex catalyzed hydrosilylation of ketones and nitriles". supporting information. . Retrieved 2020/08/13.
• 2、 Hoefnagel, A. J.,Vos, R. H. de,Wepster, B. M.. "Substituent effects. 14. Anomalous dissociation constants in water-organic solvent mixtures: benzylammonium ions and related systems". . p. 22 - 28. Retrieved 2007/10/02.