Technology Process of (6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione
There total 2 articles about (6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Bacillus megaterium DSM319 CYP106A1;
In
aq. phosphate buffer;
for 24h;
pH=7.4;
Enzymatic reaction;
DOI:10.1016/j.febslet.2015.07.011
- Guidance literature:
-
With
phosphate buffer; air; plasma of 20 d pregnant Sprague-Dawley rat;
at 37 ℃;
for 1h;
Product distribution;
metabolism with tissues (plasma, liver, brain, placenta) from mothers and fetuses of Sprague-Dawley rats sacrificed on day 20 of pregnancy and mice on day 17 of pregnancy, further in vivo;
DOI:10.1016/S0039-128X(81)90348-2