4,4'-DIMETHYLBENZOIN

Base Information

• Chemical Name: 4,4'-DIMETHYLBENZOIN
• CAS No.: 1218-89-9
• Molecular Formula: C16H16 O2
• Molecular Weight: 240.302
• Hs Code.: 2914400090
• Mol file: 1218-89-9.mol

Synonyms:p-Toluoin(6CI,7CI,8CI); 1,2-Bis(4-methylphenyl)-2-hydroxyethanone;2-Hydroxy-1,2-bis(4-methylphenyl)ethanone; 4,4'-Dimethylbenzoin; NSC 13677;p,p'-Dimethylbenzoin

Chemical Property of 4,4'-DIMETHYLBENZOIN

Chemical Property:

• Melting Point: 88oC
• Boiling Point: 422.8°Cat760mmHg
• PKA: 12.16±0.20(Predicted)
• Flash Point: 170.5°C
• PSA: 37.30000
• Density: 1.13g/cm³
• LogP: 3.21970

Purity/Quality:

99% ^*data from raw suppliers

4,4''-Dimethylbenzoin ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4'-DIMETHYLBENZOIN

There total 29 articles about 4,4'-DIMETHYLBENZOIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2-di(4-methylphenyl)-1,2-ethanedione (3457-48-5) → 4,4'-dimethylbenzoin (1218-89-9)

Guidance literature:

With aluminum tri-bromide; water; triphenylphosphine; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1055/s-2004-825581

Reference yield: 95.0%

C31H32N6OSi (111508-19-1) → 4,4'-dimethylbenzoin (1218-89-9)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 24h; Ambient temperature;

Reference yield: 94.0%

4-methyl-benzaldehyde (104-87-0) → 4,4'-dimethylbenzoin (1218-89-9)

Guidance literature:

With 1,3-dimethylbenzimidazolium Iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 1h; Heating;

DOI:10.1248/cpb.42.2633

upstream raw materials:

diethyl ether

1,2-di(4-methylphenyl)-1,2-ethanedione

triphenylmethyl bromide

ethanol

Downstream raw materials:

4,5-bis-(4-methylphenyl)-1H-imidazole

4,5-di-(p-tolyl)-Δ⁴-imidazoline-2-thione

4-Methylbenzyl alcohol

(1R,2S)-1,2-Di-p-tolyl-ethane-1,2-diol

Refernces

• 1、 Kikuchi, Satoshi,Hashimoto, Yukihiko. "Reduction of 1,2-dicarbonyl compounds mediated by the combination of phosphine and lewis acid". . p. 1267 - 1269. Retrieved 2004.
• 2、 Shen, Guoli,Liu, Haojie,Chen, Jingchao,He, Zhenxiu,Zhou, Yongyun,Wang, Lin,Luo, Yang,Su, Zhimin,Fan, Baomin. "Zinc salt-catalyzed reduction of α-aryl imino esters, diketones and phenylacetylenes with water as hydrogen source". supporting information. p. 3601 - 3610. Retrieved 2021/05/04.
• 3、 Onida, Killian,Haddleton, Alice J.,Norsic, Sébastien,Boisson, Christophe,D'Agosto, Franck,Duguet, Nicolas. "Organocatalytic Synthesis of Substituted Vinylene Carbonates". supporting information. p. 5129 - 5137. Retrieved 2021/09/18.