ETHYL 2-ETHOXYPROPIONATE

Base Information

• Chemical Name: ETHYL 2-ETHOXYPROPIONATE
• CAS No.: 7737-40-8
• Molecular Formula: C7H14O3
• Molecular Weight: 146.186
• Mol file: 7737-40-8.mol

Synonyms:NSC 61984;Propionicacid, 2-ethoxy-, ethyl ester (7CI,8CI);Ethyl 2-ethoxypropionate;Ethyl a-ethoxypropionate;

Chemical Property of ETHYL 2-ETHOXYPROPIONATE

Chemical Property:

• Vapor Pressure: 0.809mmHg at 25°C
• Refractive Index: 1.406
• Boiling Point: 182.5 °C at 760 mmHg
• Flash Point: 58.7 °C
• PSA: 35.53000
• Density: 0.947 g/cm³
• LogP: 0.97450

Purity/Quality:

99% ^*data from raw suppliers

ETHYL-2-ETHOXYPROPIONATE 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-ETHOXYPROPIONATE

There total 12 articles about ETHYL 2-ETHOXYPROPIONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) + ethyl 2-hydroxypropionate (97-64-3,2676-33-7) + ethanol (64-17-5) → ethyl 2-ethoxypropionate (7737-40-8)

Guidance literature:

(3% K2HPO4 and 0.5% H3PO4)/Al2O3; at 240 ℃; for 60h; under 7500.75 Torr; Product distribution / selectivity; Gas phase;

Reference yield: 53.0%

ethyl 2-hydroxypropionate (97-64-3,2676-33-7) + ethyl iodide (75-03-6) → ethyl 2-ethoxypropionate (7737-40-8)

Guidance literature:

ethyl 2-hydroxypropionate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1.5h; Inert atmosphere;

ethyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1055/a-1509-5655

Reference yield:

methyl 2-(trifluoroacetamido)acrylate (58137-35-2) + ketene diethyl acetal (2678-54-8) → C12H16F3NO5 + 1-trifluoroacetamido-2-ethoxy-4-oxocyclohex-2-ene-1-carboxylic acid methyl ester + ethyl 2-ethoxypropionate (7737-40-8) + orthocarbonic acid tetraethyl ester (78-09-1)

Guidance literature:

In chloroform-d1; at 25 ℃; Product distribution;

DOI:10.1039/b615220a

upstream raw materials:

ethyl 2-hydroxypropionate

ethanol

methylglyoxal diethyl acetal

2-ethoxypropionic acid

Downstream raw materials:

1,1-bis-[4-(benzyl-methyl-amino)-phenyl]-acetone

1-cyclohexyl-2-ethoxypropan-1-one

Refernces

• 1、 Sedano, Carlos,Virumbrales, Cintia,Suárez-Pantiga, Samuel,Sanz, Roberto. "Aldol-Tishchenko Reaction of α-Oxy Ketones: Diastereoselective Synthesis of 1,2,3-Triol Derivatives". supporting information. p. 3725 - 3734. Retrieved 2021/07/02.