2-AMINO-N-BENZYL-BENZAMIDE

Base Information

• Chemical Name: 2-AMINO-N-BENZYL-BENZAMIDE
• CAS No.: 5471-20-5
• Molecular Formula: C14H14N2O
• Molecular Weight: 226.278
• Hs Code.: 2924297099
• Mol file: 5471-20-5.mol

Synonyms:Benzamide,o-amino-N-benzyl- (6CI,7CI,8CI);2-Amino-N-benzylbenzamide;Anthranilic acidbenzylamide;N-(o-Aminobenzoyl)benzylamine;N-Benzyl-o-aminobenzamide;NSC26020;o-Amino-N-benzylbenzamide;2-Azanyl-N-(phenylmethyl)benzamide;

Chemical Property of 2-AMINO-N-BENZYL-BENZAMIDE

Chemical Property:

• Vapor Pressure: 1.23E-08mmHg at 25°C
• Refractive Index: 1.63
• Boiling Point: 459.7 °C at 760 mmHg
• Flash Point: 231.8 °C
• PSA: 55.12000
• Density: 1.173 g/cm³
• LogP: 3.17090

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-N-benzylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-N-BENZYL-BENZAMIDE

There total 35 articles about 2-AMINO-N-BENZYL-BENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Aminobenzyl alcohol (5344-90-1) + benzylamine (100-46-9) → 2-amino-N-benzylbenzamide (5471-20-5)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.21577/0103-5053.20180161

Reference yield: 99.0%

N-(phenylmethyl)-2-nitrobenzamide (52745-10-5) → 2-amino-N-benzylbenzamide (5471-20-5)

Guidance literature:

With tetrahydroxydiboron; 5%-palladium/activated carbon; water; In acetonitrile; at 50 ℃; for 24h;

DOI:10.1016/j.tet.2017.05.056

Reference yield: 98.0%

isatoic anhydride (118-48-9) + benzylamine (100-46-9) → 2-amino-N-benzylbenzamide (5471-20-5)

Guidance literature:

In N,N-dimethyl-formamide; at 50 - 60 ℃; for 1h; Reflux;

DOI:10.1021/acs.joc.5b00191

upstream raw materials:

isatoic anhydride

benzylamine

2-carbomethoxyaniline

2-ethoxycarbonylaniline

Downstream raw materials:

3-benzyl-2-naphthalen-1-yl-2,3-dihydro-1H-benzo[1,3,2]diazaborinin-4-one

3-benzyl-2,3-dihydro-2-phenylbenzo[d][1,3,2]diazaborinin-4(1H)-one

2-((benzylamino)methyl)aniline

3-benzyl-2-hydroxy-2,3-dihydro-1H-benzo[1,3,2]diazaborinin-4-one

Refernces

• 1、 Deng, Wei,Kambe, Nobuaki,Qiu, Renhua,Tang, Niu,Xiang, Jiannan,Yang, Tianbao,Yin, Shuang-Feng,Zeng, Dishu. "UV-Light-Induced Dehydrogenative N -Acylation of Amines with 2-Nitrobenzaldehydes to Give 2-Aminobenzamides". supporting information. . Retrieved 2022/03/17.
• 2、 Sherafati, Maedeh,Mirzazadeh, Roghieh,Barzegari, Ebrahim,Mohammadi-Khanaposhtani, Maryam,Azizian, Homa,Sadegh Asgari, Mohammad,Hosseini, Samanesadat,Zabihi, Ebrahim,Mojtabavi, Somayeh,Ali Faramarzi, Mohammad,Mahdavi, Mohammad,Larijani, Bagher,Rastegar, Hossein,Hamedifar, Haleh,Hamed Hajimiri, Mir. "Quinazolinone-dihydropyrano[3,2-b]pyran hybrids as new α-glucosidase inhibitors: Design, synthesis, enzymatic inhibition, docking study and prediction of pharmacokinetic". . . Retrieved 2021/02/26.