52745-10-5

Basic information

• Product Name: N-benzyl-2-nitrobenzamide
• Synonyms: N-benzyl-2-nitrobenzamide;2-nitro-N-(phenylmethyl)benzamide;ARONIS019353;BIM-0014056.P001;CBMicro_014070;MFCD00432683;Oprea1_062805;Oprea1_489502
• CAS NO: 52745-10-5
• Molecular Formula: C₁₄H₁₂N₂O₃
• Molecular Weight: 256.26
• Mol File: 52745-10-5.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzyl-2-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-nitrobenzamide(52745-10-5)
• EPA Substance Registry System: N-benzyl-2-nitrobenzamide(52745-10-5)

Safety Data

• Hazardous Substances Data: 52745-10-5(Hazardous Substances Data)

Upstream product

• 552-16-9 ortho-nitrobenzoic acid 
• 100-46-9 benzylamine 
• 31204-05-4 2-nitrobenzoic acid 4-nitrophenyl ester 
• 610-14-0 2-nitrobenzyl chloride 

Downstream Products

• 1848-46-0 2-benzyl-1,2-dihydro-3H-indazol-3-one 
• 1347035-20-4 N-benzyl-2-(benzylamino)benzamide 
• 401466-91-9 6-benzyl-6,6a-dihydro-9,10-dimethoxyisoindolo[2,1-a]quinazoline-5,11-dione 
• 1350616-38-4 3'-benzyl-1'H,2H-spiro[acenaphthylene-1,2'-quinazoline]-2,4'(3'H)-dione 
• 23942-38-3 4-benzyl-3a-methyl-2,3,3a,4-tetrahydropyrrolo[1,2-a]quinazolin-5(1H)-one 
• 1932-42-9 3-benzylquinazoline-2,4-dione 
• 74882-52-3 2-benzylidene-1-(2-methoxycarbonylphenyl)hydrazine 
• 4036-59-3 2-benzylidene-1-(2-carboxyphenyl)hydrazine 
• 936025-26-2 tert-butyl (S)-1-(N-benzyl-2-nitrobenzamido)-1-oxopropan-2-ylcarbamate 
• 5388-11-4 3-benzyl-3H-quinazolin-4-one 
• 5471-20-5 2-amino-N-benzylbenzamide 
• 150483-54-8 N-benzyl-2-nitrosobenzamide 

Relevant articles and documents

One-Pot Synthesis of Seven-Membered Heterocyclic Derivatives of Diazepines Involving Copper-Catalyzed Rearrangement Cascade Allyl-Amination

A novel and efficient method has been proposed for the synthesis of 1,4-benzodiazepine-5-ones from o-nitrobenzoic N-allylamides by using molybdenyl acetylacetonate and copper(II) trifluoromethanesulfonate as catalysts in the presence of triphenylphosphine. This synthesis process involves nitrene formation, C-H bond insertion, C≠C bond rearrangement, and C-N bond formation cascade reactions via copper- and molybdenum-catalyzed mediation. The method features a wide substrate scope and a moderate to high yield (up to 90%), exhibiting the possibility for practical applications.

An Efficient Catalytic Amidation of Esters Promoted by N-Heterocyclic Carbenes

An efficient NHC-catalyzed amidation between esters and amines or hydrazines is described. This strategy was tolerant for a wide scope of substrates, affording a series of amides (or hydrazides) in good to excellent yields (60-96%) under simple conditions. The approach was also used to synthesize the pharmaceutically relevant antidepressant moclobemide in 85% yield.

Preparation method of amide compounds

The invention relates to a preparation method of amide compounds. The method comprises the followings steps: feeding n-heterocyclic carbine and alkali into a reactor filled with an organic solvent inan inert gas atmosphere, stirring, sequentially feeding organic acid ester and organic amine, performing extraction through an extraction agent after reaction is accomplished, and performing chromatographic purification on residual crude products through a silicagel column, so as to obtain the amide compounds. Compared with the prior art, the method has the advantages that the n-heterocyclic carbine is taken as a catalyst, ester and amine compound rapidly form the corresponding amide compounds in the presence of the organic solvent, the reaction condition is mild, amide preparation flow is simpler and more efficient, environmentally friendly, and non-irritant, and does not generate an anaphylactic substance, the total yield is high, and volume production is easy to realize.