401466-91-9Relevant articles and documents
Synthesis of isoindolo[2,1-a]quinazoline-5,11-dione derivatives via the reductive one-pot reaction of N-substituted 2-nitrobenzamides and 2-formylbenzoic acids
Mahdavi, Mohammad,Najafi, Ramin,Saeedi, Mina,Alipour, Eskandar,Shafiee, Abbas,Foroumadi, Alireza
, p. 419 - 423 (2013)
Various isoindolo[2,1-a]quinazoline-5,11-dione derivatives 3 were synthesized in good yields by means of the reductive reaction of N-substituted 2-nitrobenzamides 1 and 2-formylbenzoic acids 2 in the presence of SnCl 2·2 H2O under reflux in EtOH (Scheme, Table). The procedure needed two steps, the reduction of the nitro group of the 2-nitrobenzamide and ring closure by nucleophilic addition of the NH2 group to both the formyl and carboxylic acid C=O groups. Copyright