4036-59-3Relevant articles and documents
Fast alpha nucleophiles: Structures that undergo rapid hydrazone/oxime formation at neutral pH
Kool, Eric T.,Crisalli, Pete,Chan, Ke Min
supporting information, p. 1454 - 1457 (2014/04/03)
Hydrazones and oximes are widely useful structures for conjugate formation in chemistry and biology, but their formation can be slow at neutral pH. Kinetics studies were performed for a range of structurally varied hydrazines, and a surprisingly large variation in reaction rate was observed. Structures that undergo especially rapid reactions were identified, enabling reaction rates that rival orthogonal cycloaddition-based conjugation chemistries.
HCV INHIBITORS
-
Page/Page column 42, (2010/11/29)
The present invention provides HCV polymerase inhibiting compounds having the formula (I) where R1is cyclobutyl-N(Ra)-, n is 1, 2, 3 or 4, and at least one R5 is RaSO2N(Rj)alkyl-. In a non-
Inhibitors of HCV NS5B polymerase: Synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines
Pratt, John K.,Donner, Pamela,McDaniel, Keith F.,Maring, Clarence J.,Kati, Warren M.,Mo, Hongmei,Middleton, Tim,Liu, Yaya,Ng, Teresa,Xie, Qinghua,Zhang, Rong,Montgomery, Debra,Molla, Akhteruzzaman,Kempf, Dale J.,Kohlbrenner, William
, p. 1577 - 1582 (2007/10/03)
N-1-Alkylamino and N-1-alkyloxy-4-hydroxyquinolon-3-yl benzothiadiazines were synthesized and evaluated as inhibitors of genotype 1 HCV polymerase. The N-1-alkyloxy derivatives were not potent inhibitors, however N-1-alkylamino derivatives displayed compa