Technology Process of Mexiletine
There total 31 articles about Mexiletine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
RS-mexiletine;
With
L-amino acid oxidase from Crotalus adamanteus; ω-transaminase from Chromobacterium violaceum DSM 30191; sodium pyruvate;
at 30 ℃;
for 24h;
pH=7;
Resolution of racemate;
aq. phosphate buffer;
With
glucose dehydrogenase; D-Alanine; D-glucose; ω-Transaminases ATA-117; C21H28N7O14P2(1+);
at 30 - 75 ℃;
optical yield given as %ee;
aq. phosphate buffer;
Enzymatic reaction;
DOI:10.1021/ol901834x
- Guidance literature:
-
With
4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; ammonium formate;
In
methanol;
at 80 ℃;
for 6h;
chemoselective reaction;
Inert atmosphere;
DOI:10.1002/chem.201303541
- Guidance literature:
-
With
ammonium formate;
In
methanol;
at 80 ℃;
for 0.166667h;
Inert atmosphere;
With
formic acid; C29H32ClIrNO; triethylamine;
In
methanol;
at 80 ℃;
Xn
