5,6-Diamino-1-methyluracil

Base Information

• Chemical Name: 5,6-Diamino-1-methyluracil
• CAS No.: 6972-82-3
• Molecular Formula: C5H8N4O2
• Molecular Weight: 156.144
• Hs Code.: 29335990
• Mol file: 6972-82-3.mol

Synonyms:Uracil,5,6-diamino-1-methyl- (6CI);3-Methyl-4,5-diaminouracil;4,5-Diamino-3-methyluracil;5,6-Diamino-1-methyl-2,4(1H,3H)-pyrimidinedione;5,6-Diamino-1-methylpyrimidine-2,4-dione;5,6-Diamino-1-methyluracil;NSC 62597;

Chemical Property of 5,6-Diamino-1-methyluracil

Chemical Property:

• Appearance/Colour: yellow powder
• Melting Point: 270°C(lit.)
• Refractive Index: 1.582
• PKA: 9.18±0.40(Predicted)
• PSA: 106.90000
• Density: 1.407 g/cm³
• LogP: -0.59960
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

6-Diamino-1-methyluracil ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F
• Hazard Codes: F
• Statements: 36/37/38-10
• Safety Statements: 26-36/37/39-16

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Diamino-1-methyluracil is used to prepare tyrosine kinase erythropoietin inhibitors producing hepatocellular carcinoma receptor B4 (EphB4).

Technology Process of 5,6-Diamino-1-methyluracil

There total 10 articles about 5,6-Diamino-1-methyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-amino-1-methyl-5-nitrosouracil (6972-78-7) → 5,6-diamino-1-methyluracil (6972-82-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In water; under 3750.3 Torr; Ambient temperature;

Reference yield: 93.0%

6-amino-1-methyluracil (2434-53-9) → 5,6-diamino-1-methyluracil (6972-82-3)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 - 25 ℃; for 2h;

Reference yield: 64.0%

C5H6N4O3 → 5,6-diamino-1-methyluracil (6972-82-3)

Guidance literature:

With ammonium hydroxide; sodium dithionite; at 60 ℃; for 1h;

DOI:10.1016/j.ijbiomac.2020.11.015

upstream raw materials:

6-amino-1-methyl-5-nitrosouracil

6-amino-1-methyl-5-phenylazo-1H-pyrimidine-2,4-dione

6-amino-1-methyluracil

N-cyanoacetyl-N'-methyl-urea

Downstream raw materials:

4-methyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione

8-Mercaptotheobromin

theobromine /

8-bromo-3,7-dimethylxanthine

Refernces

• 1、 -. "Linagliptin intermediate compound IV". Paragraph 0188; 0191. . Retrieved 2020/09/09.
• 2、 Belter, Birgit,Caflisch, Amedeo,K?ckerling, Martin,Kinski, Elisa,Mamat, Constantin,Neuber, Christin,Pietzsch, Jens,Pretze, Marc,Steinbach, J?rg. "Synthesis, radiolabelling and initial biological characterisation of 18F-labelled xanthine derivatives for PET imaging of Eph receptors". . p. 3104 - 3116. Retrieved 2020/05/08.