2-Phenylbenzaldehyde

Base Information

• Chemical Name: 2-Phenylbenzaldehyde
• CAS No.: 1203-68-5
• Molecular Formula: C13H10O
• Molecular Weight: 182.222
• Hs Code.: 29122990
• European Community (EC) Number: 627-829-6
• DSSTox Substance ID: DTXSID80923309
• Nikkaji Number: J632.182H
• Wikidata: Q72443642
• ChEMBL ID: CHEMBL124879
• Mol file: 1203-68-5.mol

Synonyms:2-Phenylbenzaldehyde;1203-68-5;2-Biphenylcarboxaldehyde;Biphenyl-2-carbaldehyde;Biphenyl-2-carboxaldehyde;[1,1'-biphenyl]-2-carbaldehyde;Biphenylcarboxaldehyde;2-formyl-1,1'-biphenyl;2-Difenilaldeide;2-Difenilaldeide [Italian];(1,1'-Biphenyl)carboxaldehyde;[1,1'-Biphenyl]carboxaldehyde;(1,1'-Biphenyl)-2-carboxaldehyde;MFCD01740431;BRN 2081880;[1,1'-Biphenyl]-2-carboxaldehyde;55171-99-8;biphenylaldehyde;biphenyl aldehyde;2-formylbiphenyl;biphenyl formaldehyde;biphenyl-2-aldehyde;2-phenyl-benzaldehyde;biphenyl carboxaldehyde;biphenyl-2 -aldehyde;2-Biphenylcarbaldehyde;2-FORMYL-BIPHENYL;SCHEMBL96494;CHEMBL124879;Biphenyl-2-carboxaldehyde, 96%;DTXSID80923309;AKOS005216888;CS-W002824;PS-8524;2,7-NAPHTHALENEDISULFONYLCHLORIDE;AC-18698;LS-44218;LS-44219;SY003223;BB 0255005;FT-0633478;EN300-51583;A25933;(1,1-biphenyl)-2-carboxaldehyde;2-difenilaldeide;J-510257;Z727783562

Chemical Property of 2-Phenylbenzaldehyde

Chemical Property:

• Vapor Pressure: 0.000146mmHg at 25°C
• Melting Point: 202 °C
• Refractive Index: n20/D >1.6220(lit.)
• Boiling Point: 332.4 °C at 760 mmHg
• Flash Point: 193.2 °C
• PSA: 17.07000
• Density: 1.095 g/cm³
• LogP: 3.16610
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, Ethyl Acetate
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 182.073164938
• Heavy Atom Count: 14
• Complexity: 182

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Phenylbenzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=CC=C2C=O
• Uses: 2-Biphenylcarboxaldehyde is a reactant used in the preparation of imidazoquinoline derivatives, a class of microsomal prostaglandin E2 synthase-1 inhibitors. 2-Biphenylcarboxaldehyde is also used in the p reparation of phenoxybenzylamino carboline derivatives as potential antitumor drugs targeting α-tubulin. Biphenyl-2-carboxaldehyde may be used in the preparation of 9-ethylthiofluorene.

Technology Process of 2-Phenylbenzaldehyde

There total 188 articles about 2-Phenylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-biphenylmethanol (2928-43-0) → 2-Phenylbenzaldehyde (1203-68-5)

Guidance literature:

With manganese(IV) oxide; In chloroform; for 5h; Heating;

DOI:10.1016/S0968-0896(97)10009-8

Reference yield: 99.0%

2-iodobenzaldehyde (26260-02-6) + phenylboronic acid (98-80-6) → 2-Phenylbenzaldehyde (1203-68-5)

Guidance literature:

With potassium carbonate; In water; at 20 ℃; for 0.5h;

DOI:10.1002/aoc.6020

Reference yield: 95.0%

phenyl trimethylsiloxane (2996-92-1,46143-12-8) + ortho-bromobenzaldehyde (6630-33-7) → 2-Phenylbenzaldehyde (1203-68-5)

Guidance literature:

With sodium hydroxide; PEG encapsulated palladium nanoparticle; In water; at 90 ℃; for 2.5h;

DOI:10.1021/ol7015143

upstream raw materials:

N-(2-phenylbenzoyl)-N'-benzensulfonylhydrazine

iodobenzene

ortho-bromobenzaldehyde

biphenyl-2-ylmagnesium iodide

Downstream raw materials:

2-biphenylmethanol

(Z)-2-(2-phenylbenzylidene)-3-quinuclidinone

α-(4'-chlorophenyl)biphenyl-2-methanol

α-(3'-fluoro-5'-isopropylphenyl)biphenyl-2-methanol

Refernces

• 1、 Jackson, Thaddeus J,Herndon, James W. "Annulation selectivity in the coupling of Fischer carbene complexes with o-alkynylbiphenyl and o-alkynylstyrene derivatives". . p. 3859 - 3868. Retrieved 2001.
• 2、 Shah, Dipen,Kaur, Harjinder. "Macroporous resin impregnated palladium nanoparticles: Catalyst for a microwave-assisted green Hiyama reaction". . p. 69 - 73. Retrieved 2012.
• 3、 Grimaldi, Tamiris B.,Lutz, Guilherme,Back, Davi F.,Zeni, Gilson. "(Biphenyl-2-alkyne) derivatives as common precursors for the synthesis of 9-iodo-10-organochalcogen-phenanthrenes and 9-organochalcogen-phenanthrenes". . p. 10415 - 10426. Retrieved 2016.
• 4、 Wang, C. X.,Yediler, A.,Peng, A.,Kettrup, A.. "PHOTODEGRADATION OF PHENANTHRENE IN THE PRESENCE OF HUMIC SUBSTANCES AND HYDROGEN PEROXIDE". . p. 501 - 510. Retrieved 1995.
• 5、 Srimani, Dipankar,Sawoo, Sudeshna,Sarkar, Amitabha. "Convenient synthesis of palladium nanoparticles and catalysis of hiyama coupling reaction in water". . p. 3639 - 3642. Retrieved 2007.
• 6、 Massaro, Marina,Riela, Serena,Lazzara, Giuseppe,Gruttadauria, Michelangelo,Milioto, Stefana,Noto, Renato. "Green conditions for the Suzuki reaction using microwave irradiation and a new HNT-supported ionic liquid-like phase (HNT-SILLP) catalyst". . p. 234 - 238. Retrieved 2014.
• 7、 Roomi,M.W.,MacDonald,S.F.. "-". . p. 139 - 143. Retrieved 1970.
• 8、 Tang, Jinghua,Luo, Meiming,Zeng, Xiaoming. "Chromium-Catalyzed, Regioselective Cross-Coupling of C-O Bonds by Using Organic Bromides as Reactants". . p. 2577 - 2580. Retrieved 2017.
• 9、 Mohanty, Sasmita,Balakrishna, Maravanji S.. "Suzuki-Miyaura, Mizoroki-Heck carbon-carbon coupling and hydrogenation reactions catalysed by PdII and RhI complexes containing cyclodiphosphazane cis-{tBuNP(OC6H4OMe-o)} 2". . p. 137 - 142. Retrieved 2010.
• 10、 Yu, Yanpeng,Hu, Tongjie,Chen, Xiaorong,Xu, Kunling,Zhang, Junli,Huang, Jun. "Pd nanoparticles on a porous ionic copolymer: A highly active and recyclable catalyst for Suzuki-Miyaura reaction under air in water". . p. 3592 - 3594. Retrieved 2011.