NSC 206120

Base Information

• Chemical Name: NSC 206120
• CAS No.: 85430-60-0
• Molecular Formula: C3H4N2O4
• Molecular Weight: 132.076
• Mol file: 85430-60-0.mol

Synonyms:3-nitro-1,3-oxazolidine-2-one;3-nitro-oxazolidin-2-one;3-Nitro-2-oxazolidinone;3-Nitro-oxazolidin-2-on;N-Nitro-oxazolidon;N-nitro-1,3-oxazolidin-2-one;

Chemical Property of NSC 206120

Chemical Property:

• Vapor Pressure: 0.102mmHg at 25°C
• Boiling Point: 222.3°Cat760mmHg
• Flash Point: 88.3°C
• PSA: 75.36000
• Density: 1.6g/cm³
• LogP: 0.09140
• Storage Temp.: Refrigerator
• Solubility.: Acetone, Chloroform, Dichloromethane, Methanol

Purity/Quality:

99% ^*data from raw suppliers

3-Nitro-2-oxazolidinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Nitro-2-oxazolidinone is an inhibitor of aldehyde dehydrogenase.This compound is suitable for aldehyde dehydrogenase (ALDH) related research. Inhibitor. Displays some specificity as an inhibitor of aldehyde dehydrogenase.

Technology Process of NSC 206120

There total 5 articles about NSC 206120 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(trimethylsilyl)-2-oxazolidinone (43112-38-5) → 3-nitro-1,3-oxazolidine-2-one (85430-60-0)

Guidance literature:

With dinitrogen pentoxide; In dichloromethane; at 0 ℃; for 0.7h;

DOI:10.1016/S0040-4020(97)00093-8

Reference yield: 76.0%

dimethylenecyclourethane (497-25-6) → 3-nitro-1,3-oxazolidine-2-one (85430-60-0)

Guidance literature:

With dinitrogen pentoxide; In carbon dioxide; at 0 - 5 ℃; for 2h; under 45004.5 - 60006 Torr; liquid CO₂;

DOI:10.1016/j.mencom.2013.03.008

Reference yield: 70.0%

dimethylenecyclourethane (497-25-6) → 3-nitroso-2-oxazolidinone (38347-74-9) + 3-nitro-1,3-oxazolidine-2-one (85430-60-0)

Guidance literature:

With Nitrogen dioxide; for 12h; under 150.01 Torr; Yields of byproduct given;

DOI:10.1021/jo00122a031

upstream raw materials:

dimethylenecyclourethane

3-(trimethylsilyl)-2-oxazolidinone

oxazolidine-2-thione

Downstream raw materials:

2-hydroxyethylnitramine

methylammonium carbonate

3-amino-2-oxazolidinone

Refernces

• 1、 Antonsen, Simen,Aursnes, Marius,Gallantree-Smith, Harrison,Dye, Christian,Stenstr?m, Yngve. "Safe synthesis of alkylhydroxy and alkylamino nitramines". . . Retrieved 2016/12/30.
• 2、 Willer, Rodney L.,Campbell, Christopher G.,Storey, Robson F.. "Synthesis of cyclic N-nitrourethanes by the simultaneous oxidative desulfurization and nitration of cyclic thiourethanes". scheme or table. p. 421 - 423. Retrieved 2012/06/18.