4-(Chloroacetyl)morpholine

Base Information

• Chemical Name: 4-(Chloroacetyl)morpholine
• CAS No.: 1440-61-5
• Molecular Formula: C6H10ClNO2
• Molecular Weight: 163.604
• Hs Code.: 29349990
• European Community (EC) Number: 215-880-3
• NSC Number: 54542
• DSSTox Substance ID: DTXSID9073258
• Nikkaji Number: J246.861A
• Wikidata: Q72516888
• Mol file: 1440-61-5.mol

Synonyms:1440-61-5;4-(2-chloroacetyl)morpholine;4-(Chloroacetyl)morpholine;Morpholine, 4-(chloroacetyl)-;N-(Chloroacetyl)morpholine;2-chloro-1-morpholinoethanone;2-chloro-1-morpholin-4-ylethanone;2-Chloro-1-(morpholin-4-yl)ethanone;2-Chloro-1-(Morpholin-4-Yl)Ethan-1-One;Chloroacetic acid morpholide;2-Chloro-1-morpholin-4-yl-ethanone;n-chloroacetylmorpholine;C6H10ClNO2;MFCD00721939;Chloroacetic acid, morpholide;2-chloro-1-morpholinoethan-1-one;N-chloroacetyl-morpholine;EINECS 215-880-3;AI3-23546;chloroacetylmorpholine;4-chloroacetylmorpholine;chloro acetyl morpholine;Ethanone, 2-chloro-1-(4-morpholinyl)-;Morpholine chloroacetamide;N-(chloroacetyl)-morpholine;4-(chloroacetyl) morpholine;4-(chloroacetyl)-morpholine;4-(Chloroacetyl)morpho line;SCHEMBL78389;4-(2-chloroacetyl) morpholine;4-(2-chloroacetyl)-morpholine;DTXSID9073258;2-morpholino-2-oxoethyl chloride;4-(Chloroacetyl)morpholine, 97%;NSC54542;STR08276;BBL034789;NSC 54542;NSC-54542;STL419472;2-chloro-1-(4-morpholinyl)-ethanone;AKOS000266941;AM86594;CS-W021985;Ethanone,2-chloro-1-(4-morpholinyl)-;LS-92582;SY019836;1-chloro-2-oxo-2-(morpholin-4-yl)ethane;BB 0217799;FT-0611690;EN300-01805;O11063;A808168;J-508617;Z56891388;F0176-0215

Chemical Property of 4-(Chloroacetyl)morpholine

Chemical Property:

• Appearance/Colour: pale yellow low melting solid
• Vapor Pressure: 0.00164mmHg at 25°C
• Melting Point: 26 °C
• Refractive Index: n20/D 1.512
• Boiling Point: 294.239 °C at 760 mmHg
• PKA: -1.26±0.20(Predicted)
• Flash Point: 131.751 °C
• PSA: 29.54000
• Density: 1.247 g/cm³
• LogP: 0.02190
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 0
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 163.0400063
• Heavy Atom Count: 10
• Complexity: 123

Purity/Quality:

99.0% ^*data from raw suppliers

4-(Chloroacetyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COCCN1C(=O)CCl
• Uses: The chloroacetyl derivatives are microbicides for adhesives, cellulose foams, oil emulsions, cooling water, etc. The chloroacetyl derivatives

Technology Process of 4-(Chloroacetyl)morpholine

There total 11 articles about 4-(Chloroacetyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + chloroacetyl chloride (79-04-9) → N-chloroacetylmorpholine (1440-61-5)

Guidance literature:

With potassium carbonate; In toluene; at 60 ℃; for 2h;

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + Chloroacetic anhydride (541-88-8) → N-chloroacetylmorpholine (1440-61-5)

Guidance literature:

In chloroform; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2017.02.009

Reference yield: 60.0%

→ N-chloroacetylmorpholine (1440-61-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

morpholine

chloroacetyl bromide

chloroacetyl chloride

Trichloroethylene

Downstream raw materials:

4-Morpholinoacetyl-morpholin

4-[N-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-glycyl]-morpholine

2-[2-(morpholin-4-yl)-2-oxoethyl]isoindoline-1,3-dione

4-[N-(2-methoxy-phenyl)-glycyl]-morpholine

Refernces

• 1、 García-Torres, Alejandro,Cruz-Almanza, Rymundo,Miranda, Luis D.. "Substitution of β-nitrostyrenes by electrophilic carbon-centered radicals". . p. 2085 - 2088. Retrieved 2004.
• 2、 Lei, Qian,Zhang, Lidan,Xia, Yong,Ye, Tinghong,Yang, Fangfang,Zhu, Yongxia,Song, Xuejiao,Wang, Ningyu,Xu, Ying,Liu, Xiaowei,Yu, Luoting. "A novel benzothiazole derivative SKLB826 inhibits human hepatocellular carcinoma growth via inducing G2/M phase arrest and apoptosis". . p. 41341 - 41351. Retrieved 2015.
• 3、 Pielichowski, Jan,Popielarz, Roman. "TRICHLOROETHYLENE IN ORGANIC SYNTHESIS: II. REACTION OF TRICHLOROETHYLENE WITH SECONDARY AMINES". . p. 2671 - 2676. Retrieved 1984.
• 4、 Alotaibi, Faez,Halaweish, Fathi,Halaweish, Hossam,Iram, Surtaj,Kasten, Abigail,Kyeremateng, Jennifer,Ostlund, Trevor. "Triazole-estradiol analogs: A potential cancer therapeutic targeting ovarian and colorectal cancer". . . Retrieved 2021/12/27.
• 5、 Abdulghani, Saba S.,Alsamarrai, Abdulmajeed S. H.. "Microwave-assisted synthesis, structural characterization and assessment of the antibacterial activity of some new aminopyridine, pyrrolidine, piperidine and morpholine acetamides". . . Retrieved 2021/06/14.