2-Furyl alpha-hydroxybenzyl ketone

Base Information

• Chemical Name: 2-Furyl alpha-hydroxybenzyl ketone
• CAS No.: 36715-43-2
• Molecular Formula: C12H10 O3
• Molecular Weight: 202.21
• NSC Number: 121397
• DSSTox Substance ID: DTXSID80298201
• Nikkaji Number: J1.397.178A
• Mol file: 36715-43-2.mol

Synonyms:36715-43-2;2-furyl |A-hydroxybenzyl ketone;1-(furan-2-yl)-2-hydroxy-2-phenylethanone;2-Furyl alpha-hydroxybenzyl ketone;NSC121397;DTXSID80298201;OAQXMQGZCPHDDV-UHFFFAOYSA-N;AKOS015906248;NSC-121397;1-(2-Furyl)-2-hydroxy-2-phenylethanone;1-(2-furanyl)-2-hydroxy-2-phenylethanone;1-(2-Furyl)-2-hydroxy-2-phenylethanone #

Chemical Property of 2-Furyl alpha-hydroxybenzyl ketone

Chemical Property:

• Vapor Pressure: 1.01E-05mmHg at 25°C
• Boiling Point: 357.2°Cat760mmHg
• Flash Point: 169.8°C
• Density: 1.242g/cm³
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 202.062994177
• Heavy Atom Count: 15
• Complexity: 221

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C(=O)C2=CC=CO2)O

Technology Process of 2-Furyl alpha-hydroxybenzyl ketone

There total 15 articles about 2-Furyl alpha-hydroxybenzyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2-bromophenyl)-1-(furan-2-yl)-2-hydroxyethan-1-one → 1-(furan-2-yl)-2-hydroxy-2-phenylethanone (36715-43-2)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; at 60 ℃; for 1.5h; Inert atmosphere; Sealed tube;

DOI:10.1039/c7ob03005c

Reference yield: 68.0%

furan-2-yl(trimethylsilyl)methanone (80671-28-9) + benzaldehyde (100-52-7) → 1-(furan-2-yl)-2-hydroxy-2-phenylethanone (36715-43-2)

Guidance literature:

With cesium fluoride; In tetrahydrofuran; for 6h; Ambient temperature;

DOI:10.1021/jo00201a029

Reference yield: 45.0%

furfural (98-01-1) + benzaldehyde (100-52-7) → 1-(furan-2-yl)-2-hydroxy-2-phenylethanone (36715-43-2)

Guidance literature:

With sodium cyanide; In ethanol; water; for 3h; Reflux;

DOI:10.1021/ol1024053

upstream raw materials:

furfural

1-cyanobenzyl benzoate

2-hydroxy-2-phenylacetophenone

benzaldehyde

Downstream raw materials:

benzaldehyde

2-furanoic acid

1-(furan-2-yl)-2-phenyl-ethane-1,2-dione

1-(furan-2-yl)-2-hydroxy-2-phenylethanone

Refernces

• 1、 Chen, Chien-Tien,Kao, Jun-Qi,Salunke, Santosh B.,Lin, Ya-Hui. "Enantioselective aerobic oxidation of α-hydroxy-ketones catalyzed by oxidovanadium(V) methoxides bearing chiral, N-salicylidene- tert -butylglycinates". supporting information; experimental part. p. 26 - 29. Retrieved 2011/03/22.
• 2、 Katritzky, Alan R.,Lang, Hengyuan,Wang, Zuoquan,Zhang, Zhongxing,Song, Huimin. "Benzotriazole-Mediated Conversions of Aromatic and Heteroaromatic Aldehydes to Functionalized Ketones". . p. 7619 - 7624. Retrieved 2007/10/03.