methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride (1:1)

Base Information

• Chemical Name: methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride (1:1)
• CAS No.: 17431-55-9
• Molecular Formula: C18H33ClN2O5S•ClH
• Molecular Weight: 461.50
• Mol file: 17431-55-9.mol

Synonyms:

Chemical Property of methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride (1:1)

Chemical Property:

• Vapor Pressure: 2.07E-18mmHg at 25°C
• Boiling Point: 628.1°Cat760mmHg
• Flash Point: 333.6°C
• Density: g/cm³

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s): Moderately toxic by ingestion.
• Hazard Codes: Moderately toxic by ingestion.

MSDS Files:

Useful:

Technology Process of methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride (1:1)

There total 8 articles about methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

clindamycin (16684-06-3,18323-44-9,51064-35-8) → clindamycin hydrochloride (21462-39-5,17431-55-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 60 ℃; for 1h; pH=1; pH-value; Temperature; Large scale;

Reference yield: 47.0%

C18H34N2O6S*ClH → clindamycin (17431-55-9)

Guidance literature:

With bis(trichloromethyl) carbonate; In chloroform; N,N-dimethyl-formamide; at 5 - 60 ℃; for 23h;

Reference yield:

→ clindamycin hydrochloride (21462-39-5,17431-55-9)

Guidance literature:

upstream raw materials:

lincomycin hydrochloride

2,3,4-tris-O-(trimethylsilyl)lincomycin

lincomycin

clindamycin

Downstream raw materials:

3,4-o-isopropylideneclindamycin

C₂₁H₃₇ClN₂O₅S

C₃₃H₅₄N₄O₁₁S₃

Refernces

• 1、 -. "Preparation method for clindamycin hydrochloride". Paragraph 0018; 0019; 0020; 0021; 0022; 0023-0041. . Retrieved 2017/07/04.
• 2、 -. "Process and device for producing liquid dosage formulations of medicinal compounds on demand from tablets and capsules". . . Retrieved 2008/06/13.